A Novel Low‐Pressure Device for Production of Nanoemulsions

Abstract

A novel device is applied to produce emulsions of methyl methacrylate in water with a controllable size in the range of 30–100 nm. The process is based on the reciprocating flow of the material through an abrupt contraction which generates a strong elongational flow. This results in highly efficient dispersive mixing even at moderate pressures, thus reducing viscous dissipation and improving temperature control. The original design of the device also allows easy feeding and sampling, easy adjusting of the total volume of the emulsion, and processing volatile components owing to the liquid‐ and gas‐tightness of the device. The influence of process parameters (like pressure drop and mixing time) and composition of the system (volume ratio of the dispersed and continuous phases, surfactant and hydrophobic agent weight percentages) on the droplet size and stability of the emulsions is investigated and discussed.

Microfluidic conceived Trojan microcarriers for oral delivery of nanoparticles

“…In our trials, a plateau value was obtained after 329 90 cycles. Such observation was also reported bySouilem et al Souilem et al, 2012) who claimed that equilibrium is reached 331 between the forces resulting from the Laplace pressure (Eq.…”

“…This nanoemulsification was produced by 143 means of an elongation-flow micromixer (mRMX, Fig. 1a) having a 144 restriction of 250 mm, a miniaturized version of a bigger RMX 1 145 developed by (Souilem et al, 2012). Authors have shown that due 146 to its specific design, such device promotes a predominant 147 elongational flow, which is known to be more efficient than shear and imaged by the confocal microscope Leica SP2 using a 20Â dry (Table 1).…”

Development of an Elongational‐Flow Microprocess for the Production of Size‐Controlled Nanoemulsions: Batch Operation

“…By using these emulsification methods, the nanodroplets can be obtained by energy transfer with the presence of surfactant whose function is to decrease the interfacial tension. Our group has recently developed a new concept of reactor/mixer (called RMX) which was successfully used to produce nanoemulsions whose size can be controlled in the range 30–100 nm . The working principle of this pneumatic apparatus is based on the reciprocating flow of a crude emulsion through an abrupt contraction which generates a strong elongational‐flow, known to be more efficient, in contrast to shear flow, to rupture dispersed phase droplets into smaller ones.…”

Dimensional analysis of a novel low‐pressure device for the production of size‐tunable nanoemulsions

“…Farzi et al have shown the feasibility of nanoemulsions using such kind of mixer. Another generation of static mixers relying on the principle of elongational flow was recently designed …”