A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways

Tsai, Kun Ling; Huang, Yi Hsiang; Kao, Chung Lan; Yang, De Ming; Lee, Hsin Chen; Chou, Hsiang; Chen, Yu‐Chih; Chiou, Guang Yuh; Chen, Li Hsin; Yang, Yi; Chiu, Te-Fa; Tsai, Chiou Sheng; Ou, Hsiu Chung; Chiou, Shih Hwa

doi:10.1016/j.jnutbio.2011.01.011

Cited by 117 publications

(96 citation statements)

References 36 publications

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“…Tsai et al [14] seen that CoQ10 rescued dephosphorylation of AMP-activated protein kinase (AMPK) caused by Ox-LDL. In addition, CoQ10 attenuated the Ox-LDL-induced generation of reactive oxygen species (ROS) [15]. Prior genetic and epidemiologic studies have shown that Ox-LDL and Lp(a) are risk factors of atherosclerotic diseases such as CHD [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome

Rahmani

Jamilian

Samimi

et al. 2017

Gynecological Endocrinology

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Objective: This research was conducted to assess the effects of coenzyme Q10 (CoQ10) intake on gene expression related to insulin, lipid and inflammation in subjects with polycystic ovary syndrome (PCOS). Methods: This randomized double-blind, placebo-controlled trial was conducted on 40 subjects diagnosed with PCOS. Subjects were randomly allocated into two groups to intake either 100 mg CoQ10 (n ¼ 20) or placebo (n ¼ 20) per day for 12 weeks. Gene expression related to insulin, lipid and inflammation were quantified in blood samples of PCOS women with RT-PCR method.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome

Rahmani

Jamilian

Samimi

et al. 2017

Gynecological Endocrinology

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“…In vitro analyses on human umbilical vein endothelial cells demonstrated that CoQ10 supplementation reduced oxidized low-density lipoproteininduced endothelin-1 (a known potent vasoconstrictor) secretion. 15 Furthermore, CoQ10 supplementation increased nitric oxide bioavailability and decreased cytochrome c (required for activation of proapototic proteins) secretion.…”

Section: Sharma Et Almentioning

confidence: 99%

Coenzyme Q10 and Heart Failure

Sharma

Fonarow

Butler

et al. 2016

Circ: Heart Failure

123

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Abstract-Heart failure (HF) with either preserved or reduced ejection fraction is associated with increased morbidity and mortality. Evidence-based therapies are often limited by tolerability, hypotension, electrolyte disturbances, and renal dysfunction. Coenzyme Q10 (CoQ10) may represent a safe therapeutic option for patients with HF. CoQ10 is a highly lipophilic molecule with a chemical structure similar to vitamin K. Although being a common component of cellular membranes, CoQ10's most prominent role is to facilitate the production of adenosine triphosphate in the mitochondria by participating in redox reactions within the electron transport chain. Numerous trials during the past 30 years examining CoQ10 in patients with HF have been limited by small numbers and lack of contemporary HF therapies. The recent publication of the Q-SYMBIO randomized controlled trial demonstrated a reduction in major adverse cardiovascular events with CoQ10 supplementation in a contemporary HF population. Although having limitations, this study has renewed interest in evaluating CoQ10 supplementation in patients with HF. Current literature suggests that CoQ10 is relatively safe with few drug interactions and side effects. Furthermore, it is already widely available as an over-the-counter supplement. These findings warrant future adequately powered randomized controlled trials of CoQ10 supplementation in patients with HF. This state-of-the-art review summarizes the literature about the mechanisms, clinical data, and safety profile of CoQ10 supplementation in patients with HF. (Circ Heart Fail. 2016;9:e002639.

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“…Coenzyme Q10 has consistent and significant antihypertensive effects in patients with essential hypertension [1,[308][309][310][311][312][313][314][315][316][317] . The literature is summarized below: (1) Compared to normotensive patients, essential hypertensive patients have a higher incidence (6 fold) of coenzyme Q10 deficiency documented by serum levels [1] ; (2) Doses of 120 to 225 mg/d of coenzyme Q10, depending on the delivery method or the concomitant ingestion with a fatty meal, are necessary to achieve a therapeutic level of 3 ug/mL [1,313,314] .…”

Section: Coenzyme Q10 (Ubiquinone)mentioning

confidence: 99%

“…Both total dose and frequency of administration may be reduced. (7) Patients administered coenzyme Q10 with enalapril improved the 24 h ABM better than with enalapril monotherapy and also normalized endothelial function [310] ; and (8) Coenzyme Q10 is a lipid phase antioxidant and free radical scavenger, increases eNOS and NO, reduces inflammation and NF-κB and improves endothelial function and vascular elasticity [1,311,312] . Other favorable effects on cardiovascular risk factors include improvement in the serum lipid profile and carbohydrate metabolism with reduced glucose and improved insulin sensitivity, reduced oxidative stress, reduced heart rate, improved myocardial LV function and oxygen delivery and decreased catecholamine levels [1,311,312] .…”

Section: Coenzyme Q10 (Ubiquinone)mentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways

Cited by 117 publications

References 36 publications

RETRACTED ARTICLE: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome

RETRACTED ARTICLE: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome

Coenzyme Q10 and Heart Failure

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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