A Novel Mechanism of Starvation‐Stimulated Hepatic Autophagy

Shen, Yang; Czaja, Mark J.

doi:10.1002/hep.30118

Cited by 6 publications

(8 citation statements)

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“…Additionally, researches have also shown that Ca 2+ plays an indispensable role in the autophagy process [ 157 ]. Autophagy is a smart evolutionary process of transformation of eukaryotes [ 158 , 159 ].…”

Section: Calcium-based Nanomaterials For Cancer Diagnosis and Therapymentioning

confidence: 99%

Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

Bai

Lan

et al. 2022

Nano-Micro Lett.

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As the indispensable second cellular messenger, calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins. The importance of calcium ions (Ca2+) makes its “Janus nature” strictly regulated by its concentration. Abnormal regulation of calcium signals may cause some diseases; however, artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role. “Calcium overload,” for example, is characterized by excessive enrichment of intracellular Ca2+, which irreversibly switches calcium signaling from “positive regulation” to “reverse destruction,” leading to cell death. However, this undesirable death could be defined as “calcicoptosis” to offer a novel approach for cancer treatment. Indeed, Ca2+ is involved in various cancer diagnostic and therapeutic events, including calcium overload-induced calcium homeostasis disorder, calcium channels dysregulation, mitochondrial dysfunction, calcium-associated immunoregulation, cell/vascular/tumor calcification, and calcification-mediated CT imaging. In parallel, the development of multifunctional calcium-based nanomaterials (e.g., calcium phosphate, calcium carbonate, calcium peroxide, and hydroxyapatite) is becoming abundantly available. This review will highlight the latest insights of the calcium-based nanomaterials, explain their application, and provide novel perspective. Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.

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Section: Calcium-based Nanomaterials For Cancer Diagnosis and Therapymentioning

confidence: 99%

Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

Bai

Lan

et al. 2022

Nano-Micro Lett.

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“…Indeed, autophagy has been considered as an emerging metabolic regulatory pathway in skeletal muscle, and its role in skeletal muscle metabolism and atrophic diseases has been extensively studied [ 212 , 213 ]. In skeletal muscle autophagy signal transduction, mTOR, AMPK, AKT and FoxO3, as important central trophic effectors, regulate autophagy process according to nutritional status, and their interaction with OGT is inseparable [ 214 , 215 , 216 , 217 ]. Given the critical role of O -GlcNAcylation in these processes, O -GlcNAcylation may affect autophagy flux and proteostasis to regulate skeletal muscle mass and proteolysis [ 206 ].…”

Section: O -Glcnacylation Autophagy and Skeletal Muscle Path...mentioning

confidence: 99%

“…Meanwhile, Caenorhabditis elegans bearing null mutations of ogt-1 or oga-1 increases autophagy under food deprivation-induced starvation [ 224 , 225 ]. Genetic ablation of OGT in mouse livers also affects autophagic flux under similar deprivation [ 25 , 216 ]. For example, the reduction of OGT in Drosophila was associated with the increase of autophagy-related gene (ATG) product and autophagy lysosomes [ 226 ].…”

Section: O -Glcnacylation Autophagy and Skeletal Muscle Path...mentioning

confidence: 99%

Protein O-GlcNAcylation in Metabolic Modulation of Skeletal Muscle: A Bright but Long Way to Go

Liu

2022

Metabolites

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O-GlcNAcylation is an atypical, dynamic and reversible O-glycosylation that is critical and abundant in metazoan. O-GlcNAcylation coordinates and receives various signaling inputs such as nutrients and stresses, thus spatiotemporally regulating the activity, stability, localization and interaction of target proteins to participate in cellular physiological functions. Our review discusses in depth the involvement of O-GlcNAcylation in the precise regulation of skeletal muscle metabolism, such as glucose homeostasis, insulin sensitivity, tricarboxylic acid cycle and mitochondrial biogenesis. The complex interaction and precise modulation of O-GlcNAcylation in these nutritional pathways of skeletal muscle also provide emerging mechanical information on how nutrients affect health, exercise and disease. Meanwhile, we explored the potential role of O-GlcNAcylation in skeletal muscle pathology and focused on its benefits in maintaining proteostasis under atrophy. In general, these understandings of O-GlcNAcylation are conducive to providing new insights into skeletal muscle (patho) physiology.

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“…Autophagy is initiated by formation of the isolation membrane (double‐membrane phagophore), and the extended phagophore engulfs target organelles and transports them to lysosomes for degradation 7,8 . After lysosomal degradation, recycling replenishes the cell with nutrients 9,10 . Our interest is in the association of autophagy with liver diseases 11 .…”

Section: Introductionmentioning

confidence: 99%

“…7,8 After lysosomal degradation, recycling replenishes the cell with nutrients. 9,10 Our interest is in the association of autophagy with liver diseases. 11 For example, we found that autophagy is an independent risk factor of recurrence after patients with HCC with large tumors undergo surgery.…”

Section: Introductionmentioning

confidence: 99%