A Novel Mesoporous Biomaterial for Treating Dentin Hypersensitivity

Abstract

An ideal material has yet to be discovered that can completely treat dentin hypersensitivity; however, calcium phosphate precipitation has exhibited potential value for the treatment of dentin hypersensitivity by the occlusion of dentinal tubules. We hypothesized that a novel mesoporous silica biomaterial (nano CaO@mesoporous silica, NCMS) containing nano-sized calcium oxide particles mixed with 30% phosphoric acid can efficiently occlude dentinal tubules and significantly reduce dentin permeability, even with the presence of pulpal pressure. This highly supersaturated Ca(2+)-and HPO(4)(2-)ion-containing NCMS paste was brushed onto dentin surfaces, and the ions diffused deeply into the dentinal tubules and formed a CaHPO(4).2H(2)O precipitation with a depth of 100 microm. The results of the dentin permeability tests showed that the novel mesoporous material exhibited a significant reduction in dentin permeability (p < 0.05), even under simulated pulpal pressure, as compared with our previously developed material, DP-bioglass, and a commercial desensitizing material, Seal & Protect.

Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

“…They include light-cured bonding materials 5) , strontium chloride, sodium fluoride 6) , potassium nitrate and potassium oxalate 7) , silica 8) , calcium-based remineralizing agents [9][10][11][12] , and nanosized carbonate apatite 13) . Some dentin hypersensitivity treatment products contain a variety of chemical agents.…”

“…CPP occluding agents may provide twofold functions in the initial mechanical plugging and in long-term remineralization. In previous studies [10][11][12] , occlusion of dentinal tubules was obtained by wiping a mixture of calcium and phosphate on the dentinal surface. CPP which forms in this way on the dentinal surface cannot deeply penetrate into the dentinal tubules.…”

Seal that Heals

“…The oxalate ions react with calcium ions in the dentinal fluid to form insoluble calcium oxalate crystals that block the tubules and prevent fluid movement, reducing sensitivity. 4,9,10 Potassium oxalate is effective, easy to apply, safe, relatively inexpensive and well-tolerated by patients. Hence, it was used in this study.…”

Análise quantitativa e qualitativa da condutividade hidráulica da dentina após tratamento com diferentes agentes dessensibilizantes. Estudo in vitro

“…Outra opção de tratamento da HD, recentemente comprovada e lançada no mercado, é o uso de produtos bioativos, cuja bioatividade está baseada na avançada tecnologia de nanopartículas de fosfato de cálcio organizado na forma cristalina de hidroxiapatita (CHIANG et al, 2010;SUN et al, 2010).…”

“…Junto a isso, a presença do flúor complementa esse efeito dessensibilizante (CHIANG et al, 2010;SUN et al, 2010). Nesse sentido, a FGM lança na sua linha de produtos o Desensibilize Nano P.…”