A novel metastable β-type Zr-12Nb-4Sn alloy with low Young's modulus and low magnetic susceptibility

Guo, Shun; Zhang, Jinming; Shang, Yao; Zhang, Junsong; Meng, Qingkun; Cheng, Xiaonong; Zhao, Xiaohu

doi:10.1016/j.jallcom.2018.02.088

Cited by 25 publications

(5 citation statements)

References 31 publications

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“…Figure 3 also shows that while the Zr-based materials have the lowest magnetic susceptibilities, the Ti-based materials are the second lowest magnetic susceptibilities. Nonetheless, Ti-6Al-4V and cp Ti-Gr2 still exhibit values almost three or two times larger than the Zr-based materials, consistent with previous investigations 7,10,11,17,28,30 . Based on these promising results, it is usually claimed that the reduced magnetic susceptibilities of Zr-based materials could sharply reduce the occurrence of MRI artifacts.…”

Section: Resultssupporting

confidence: 91%

Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Suzuki

Campo

Fonseca

et al. 2020

Sci Rep

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this study compared Zr-Mo alloys with commercial metallic biomaterials. it was observed that the Zr-Mo alloys exhibited favourable mechanical properties, particularly the Zr-10Mo alloy, which showed the highest strength to Young's modulus ratio among all evaluated metals. these alloys also exhibited the lowest magnetic susceptibilities, which are important for magnetic resonance imaging (MRi). However, both Zr-and ti-based metals yielded comparable artifacts. it was concluded that the magnetic susceptibility must differ considerably to afford significantly improved MRI quality owing to the increased importance of non-susceptibility-related artifacts when comparing materials with relatively similar magnetic susceptibilities. Metals are still competitive with other classes of materials in the application and development of medical implants in various fields of medicine, such as orthopaedics, neurology, cardiology, and dentistry. Owing to their combined properties, including strength and toughness, and the possibility of employing cost-effective manufacturing processes, metals are typically the best biomaterial choice when compared to ceramics and polymers, as well as composites. The use of metallic devices in the human body is usually required for the replacement and stabilization of damaged bone tissues in orthopaedic practice. The classical examples of such applications include temporary plates and screws, and permanent total hip replacements. Other applications include usage in vascular stents, aneurysm clips, pacemakers, dental implants, wire sutures, etc. 1-3. Despite being similar to Ti alloys, particularly in their physical metallurgy and other properties 4 , Zr-based alloys have received comparatively little attention as biomaterials. Zr and its alloys exhibit excellent biocompatibility, good corrosion behaviour, and favourable mechanical properties 5-11. Specifically, these alloys are suitable for applications in orthopaedic and dentistry owing to their low Young's modulus. A major issue associated with using metallic materials in long-term implants is the mismatch between the bone and the employed device. Rigid implants can promote the stress shielding effect and cause bone resorption, strongly affecting the medium-to long-term quality of the surgical intervention 12. Accordingly, alloys with a low Young's modulus have been targeted for this type of application 13,14. In this regard, Zr alloys are similar to Ti alloys. For instance, Guo et al. 10 reported a Young's modulus of only 44 GPa for a β-type Zr-12Nb-4Sn alloy, which is relatively close to that of human cortical bone (around 20 GPa 15) and is similar to as the best results reported for Ti alloys 16. More recently, increasing interest in Zr and its alloys has been justified by their reduced magnetic susceptibility, which has been claimed to reduce the magnetic resonance imaging (MRI) artifacts 7,10,11,17,18. MRI is a powerful non-invasive tool for medical diagnosis that relies on the nuclear magnetic resonance phenomenon. It presents a high spatial...

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Section: Resultssupporting

confidence: 91%

Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Suzuki

Campo

Fonseca

et al. 2020

Sci Rep

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“…Their intention was to investigate the properties of β phase, whose precipitates were too small in Zr-2.5Nb alloy, rather than using the Zr-19Nb alloy in practice. Zr-based alloys with retained β phase at room temperature such as Zr-(12-40)Nb [ 26 ], Zr-4Mo-4Sn [ 27 ] or Zr-12Nb-4Sn [ 28 ] are currently studied for manufacturing of medical implants with low elastic modulus and low magnetic susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Novel α + β Zr Alloys with Enhanced Strength

et al. 2021

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Low-alloyed zirconium alloys are widely used in nuclear applications due to their low neutron absorption cross-section. These alloys, however, suffer from limited strength. Well-established guidelines for the development of Ti alloys were applied to design new two-phase ternary Zr alloys with improved mechanical properties. Zr-4Sn-4Nb and Zr-8Sn-4Nb alloys have been manufactured by vacuum arc melting, thermo-mechanically processed by annealing, forging, and aging to various microstructural conditions and thoroughly characterized. Detailed Scanning electron microscopy (SEM) analysis showed that the microstructural response of the alloys is rather similar to alpha + beta Ti alloys. Duplex microstructure containing primary alpha phase particles surrounded by lamellar alpha + beta microstructure can be achieved by thermal processing. Mechanical properties strongly depend on the previous treatment. Ultimate tensile strength exceeding 700 MPa was achieved exceeding the strength of commercial Zr alloys for nuclear applications by more than 50%. Such an improvement in strength more than compensates for the increased neutron absorption cross-section. This study aims to exploit the potential of alpha + beta Zr alloys for nuclear applications.

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“…M-H curves of Zr-Ru alloy obtained using a magnetometer at room temperature exhibited linear variation relationship. Most recently, Guo et al reported a magnetic susceptibility of 1.42 × 10 −6 in a metastable beta-type Zr-12Nb-4Sn alloy [173]. Moreover, quantitative determination of the magnetic force exerted on a stent in MRI magnet is also significant as large susceptibility of stent material, higher magnetic field, and larger gradient can increase the magnetic force on metallic implant upon entering an MRI magnet [174].…”

Section: Magnetic Susceptibilitymentioning

confidence: 99%

Balloon expandable coronary stent materials: a systematic review focused on clinical success

et al. 2022

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Balloon expandable coronary stenting has revolutionized the field of interventional cardiology as a potential, minimally invasive modality for treating coronary artery disease. Even though stenting is successful compared to angioplasty (that leaves no stent in place), still there are many associated clinical complications. Bare metal stents are associated with in-stent restenosis caused mostly by neointimal hyperplasia, whereas success of drug-eluting stents comes at the expense of late-stent thrombosis and neoatherosclerosis. Even though innovative and promising, clinical trials with bioabsorbable stents reported thrombosis and a rapid pace of degradation without performing scaffolding action in several instances. It should be noted that a vast majority of these stents are based on a metallic platform which still holds the potential to mitigate major cardiovascular events and reduced economic burden to patients, alongside continuous improvement in stent technology and antiplatelet regimes. Hence, a systematic review was conducted following PRISMA guidelines to assess the clinically relevant material properties for a metallic stent material. From a materials perspective, the major causes identified for clinical failure of stents are inferior mechanical properties and blood-material interaction-related complications at the stent surface. In addition to these, the stent material should possess increased radiopacity for improved visibility and lower magnetic susceptibility values for artefact reduction. Moreover, the review provides an overview of future scope of percutaneous coronary interventional strategy. Most importantly, this review highlights the need for an interdisciplinary approach by clinicians, biomaterial scientists, and interventional cardiologists to collaborate in mitigating the impediments associated with cardiovascular stents for alleviating sufferings of millions of people worldwide.

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A novel metastable β-type Zr-12Nb-4Sn alloy with low Young's modulus and low magnetic susceptibility

Cited by 25 publications

References 31 publications

Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Appraising the potential of Zr-based biomedical alloys to reduce magnetic resonance imaging artifacts

Novel α + β Zr Alloys with Enhanced Strength

Balloon expandable coronary stent materials: a systematic review focused on clinical success

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