A novel method based on curvature analysis for estimating the dietary vitamin K requirement in adolescents

Tsugawa, Naoko; Uenishi, Kazuhiro; Ishida, Hiromi; Minekami, Takuya; Doi, Ayako; Koike, S; Takase, Tomoki; Kamao, Maya; Mimura, Yoshio; Okano, Toshio

doi:10.1016/j.clnu.2011.10.006

Cited by 15 publications

(19 citation statements)

References 25 publications

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“…AIs of vitamin K for bone health have not been evaluated in the DRI so far, and further research is needed. The result of our study [ 29 ] inferred that the required vitamin K level for bone formation was 3 times higher than that for blood clotting, suggesting that the effect of vitamin K deficiency is more prominent on bone rather than on blood clotting in adolescents ( Figure 3 ). A similar phenomenon was also reported in adults.…”

Section: Negative Correlation Between Vitamin K Status and Uncarbomentioning

confidence: 79%

“…Several studies showed a negative association between serum uncarboxylated VKDP levels and vitamin K status or dietary vitamin K intake ( Table 2 ) [ 15 , 18 , 20 , 23 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. However, these studies had no established criteria for detecting vitamin K deficiency in tissues.…”

Section: Negative Correlation Between Vitamin K Status and Uncarbomentioning

confidence: 99%

“…However, these studies had no established criteria for detecting vitamin K deficiency in tissues. To address this, in our previous work, we established a new method for estimating vitamin K intake by curvature analysis using the serum levels of ucOC or PIVKA-II [ 29 ]. We used a logarithmic regression equation obtained from vitamin K intake values and serum ucOC or PIVKA-II levels.…”

Section: Negative Correlation Between Vitamin K Status and Uncarbomentioning

confidence: 99%

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Vitamin K Nutrition and Bone Health

Tsugawa

Shiraki²

2020

Nutrients

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Vitamin K is essential for blood coagulation and plays an important role in extrahepatic metabolism, such as in bone and blood vessels, and in energy metabolism. This review discusses the assessment of vitamin K sufficiency and the role of vitamin K in bone health. To elucidate the exact role of vitamin K in other organs, accurate tools for assessing vitamin K deficiency or insufficiency are crucial. Undercarboxylated vitamin K-dependent protein levels can be measured to evaluate tissue-specific vitamin K deficiency/insufficiency. Vitamin K has genomic action through steroid and xenobiotic receptor (SXR); however, the importance of this action requires further study. Recent studies have revealed that the bone-specific, vitamin K-dependent protein osteocalcin has a close relationship with energy metabolism through insulin sensitivity. Among the organs that produce vitamin K-dependent proteins, bone has attracted the most attention, as vitamin K deficiency has been consistently associated with bone fractures. Although vitamin K treatment addresses vitamin K deficiency and is believed to promote bone health, the corresponding findings on fracture risk reduction are conflicting. We also discuss the similarity of other vitamin supplementations on fracture risk. Future clinical studies are needed to further elucidate the effect of vitamin K on fracture risk.

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Section: Negative Correlation Between Vitamin K Status and Uncarbomentioning

confidence: 79%

Section: Negative Correlation Between Vitamin K Status and Uncarbomentioning

confidence: 99%

Section: Negative Correlation Between Vitamin K Status and Uncarbomentioning

confidence: 99%

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Vitamin K Nutrition and Bone Health

Tsugawa

Shiraki²

2020

Nutrients

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“…Furthermore, because the assessment items for dietary vitamin K intake were limited to nine vitamin K–rich foods, the minimum dietary vitamin K intake was 0 and the dietary vitamin K intake tended to decrease during the study period. To make the dietary assessment more closely reflect the entire dietary vitamin K intake, in future we will have to select more sophisticated methods: for example, we may need to estimate each participant’s dietary intake of not only vitamin K but also other nutritional components [9, 10]. We will also need to investigate the lowest effective dose by measuring other bone metabolism parameters in a randomized, double-blind, placebo-controlled study that considers the dietary habits and genotypes of the subjects [19].…”

Section: Discussionmentioning

confidence: 99%

Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study

Nakamura

Aoki

Watanabe

et al. 2014

Nutr J

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BackgroundMenaquinone-4 is a type of vitamin K that has a physiological function in maintaining bone quality via γ-carboxylation of osteocalcin. However, little is known about the beneficial effect of intake of dosages below1500 μg/day.FindingsFifteen healthy males aged 25.0 years (median) participated in a non-placebo-controlled dose-examination study. They received menaquinone-4 daily for 5 weeks at 0, 300, 600, 900, and 1500 μg/day in weeks 1, 2, 3, 4, and 5, respectively. Compared with baseline, serum γ-carboxylated osteocalcin levels were significantly greater at an intake of 900 μg/day or more; serum undercarboxylated osteocalcin levels and the ratio of serum undercarboxylated osteocalcin to γ-carboxylated osteocalcin were significantly lower than baseline at doses of 600 μg/day or more.ConclusionsThis preliminary graded-dose study suggested that menaquinone-4 supplementation at 600 μg/day or more is likely to be important in terms of vitamin K requirements for bone health.

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“…33 Little research has been done to evaluate adolescents' vitamin K requirements for optimal bone development, but recent papers indicate that vitamin K status plays an important role in children's bone health, 34 and that bone metabolism requires significantly more vitamin K than blood coagulation. 35 Given the abysmally low intake of foods rich in vitamin K in the US population, for example, broccoli, leafy greens, and unhydrogenated vegetable oils (hydrogenation detrimentally changes the chemical structure of vitamin K), vitamin K insufficiency in adolescents is very high. Research evaluating vitamin K intake found that only half the females age 13 and over and less than half the males got the recommended daily allowance of vitamin K, which recent evidence suggests is not sufficient for maximizing the function of vitamin K in bones.…”

Section: The Seeds Of Osteoporosis Are Sown In Adolescencementioning

confidence: 99%

Osteoporosis: The Need for Prevention and Treatment

Baucom¹,

Pizzorno²,

Pizzorno³

2014

j restorat med

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Osteoporosis is a preventable, potentially crippling disease characterized by low bone density and increased bone fragility that affects millions of people. The seeds of this pernicious disease are sown during adolescence, when the skeleton is most active in absorbing dietary calcium and building up nearly all the bone mass that will carry the teenager throughout life. Dietary intake of calcium, vitamin D and vitamin K, particularly vitamin K2, is critical during this life stage for optimal bone growth; unfortunately, the majority of adolescents in the USA do not consume adequate amounts. In addition, many adolescents are now using oral contraceptives or intrauterine devices that prevent ovulation, thus inhibiting formation of progesterone required for the development of osteoblasts. Oral contraceptives also lower blood levels of vitamins B6 and B12, both of which are necessary to prevent elevated levels of homocysteine, whose impact on bone can be significant. In addition to "the pill," many commonly prescribed medications disrupt normal bone remodeling and promote osteoporosis. Other remediable factors that cause excessive bone loss include insufficiencies of key nutrients, such as vitamin D3, vitamin K2, and calcium, required for healthy bone remodeling. It is important to recognize key risk factors and manage those that can be modified to prevent disease and/or minimize risk of fracture. This article presents an overview of osteoporosis, pathophysiology of disease, diagnostic tests, risk factors, and clinical recommendations for healthy bones.

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A novel method based on curvature analysis for estimating the dietary vitamin K requirement in adolescents

Cited by 15 publications

References 25 publications

Vitamin K Nutrition and Bone Health

Vitamin K Nutrition and Bone Health

Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study

Osteoporosis: The Need for Prevention and Treatment

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