A novel micro-well array chip for liquid phase biomaterial processing and detection

Development of an integrated CMOS DNA detection biochip

“…Thus, the development of an accurate, portable and relatively inexpensive biosensor has become one of the most important issues in the healthcare industry. The introduction of complementary metal oxide semiconductor (CMOS) chips for DNA identification may overcome traditional problems and satisfy the requirements for inexpensive, accurate, and rapid detection because the fabrication processes for CMOS biochips are so mature that the detection circuit for CMOS biochips can be less than 1 m. Many CMOS or CMOS-process compatible biochips have been introduced using two typical DNA detection methods, namely an optical approach [1][2][3][4] and an electrochemical approach [5][6][7][8][9].…”

Curved Microwell Arrays Created by Diffusion-Limited Chemical Etching of Artificially Engineered Solids

“…The spacing and the diameter of the structures are determined by the sizes of starting glasses and drawing and etching conditions. Previously, the fiber-drawing method has been used to fabricate glass nanochannel and nanocone arrays and vertically aligned alloy and semiconductor micro/nanowires. − This work extends the application of fiber drawing to the high-yield controlled production of curved microwells, which could be used as an enabling tool for high-throughput synthesis, analysis, and screening of materials and biomolecules. − This method is intended to be complementary rather than replace photolithography techniques that have much better structural controls in making large samples at low cost. Compared to photolithography, this method provides a new mechanism by which we could intentionally control the surface reactivity of a solid material at certain locations.…”

Wafer-Scale Fabrication of Polymer-Based Microdevices via Injection Molding and Photolithographic Micropatterning Protocols

“…16,27 Temperature modulation with integrated microcomponents for heating and sensing is of practical importance as it offers precise control of reactions or fluidics without mechanical manipulation. It has been applied in the modulation of biomolecule binding, [28][29][30] cell manipulation, 13 microreactors, [31][32][33][34][35] microfluidics, [35][36][37][38] and other biochemical processes on surfaces. [39][40][41] On the other hand, integrated microelectrodes have been used for electrochemical detection, 41 for immobilization of biomolecules, 26 and for microfluidic control.…”

“…Temperature modulation with integrated microcomponents for heating and sensing is of practical importance as it offers precise control of reactions or fluidics without mechanical manipulation. It has been applied in the modulation of biomolecule binding, − cell manipulation, microreactors, − microfluidics, − and other biochemical processes on surfaces. − On the other hand, integrated microelectrodes have been used for electrochemical detection, for immobilization of biomolecules, and for microfluidic control. , Therefore, preparation and integration of micropatterns for heating and temperature sensing as well as microelectrodes for electrochemical reactions on a polymer substrate is critical to the development of the next generation of biomedical microdevices. To date, the integrated components on polymer substrates include microelectrodes on PMMA for immunosensing, resistive thermal devices on PC for DNA mutation detection, microelectrodes on PMMA for electroporation, and conductivity detector on PMMA for istachophoresis. , …”