A Novel Microcrystalline Tyrosine-Adsorbed, Mite-Allergoid Subcutaneous Immunotherapy: 1-Year Follow-Up Report

Abstract

Significant decreases in clinical symptoms and immunological parameters were observed, accompanying a high level of patient satisfaction and tolerance.

Clinical trial to assess tolerability and subrogate efficacy effects of an abbreviated schedule with house dust mites mixture subcutaneous immunotherapy

“…This depot formulation induced an early immunological response, confirmed by statistically significant increments of sIgG and sIgG4 levels against DPT and DF, after approximately 3 months of therapy. Similar results could be observed in other studies, where a fast increase in sIgG and sIgG4 can be associated with the effect of blocking IgEbinding to allergens and immune response modification (26,30,31). These results are in line with the immunologic and skin prick test outcomes observed in previous studies with DPT 100% (Allergovac® depot, ROXALL Medicina España S.A., Zamudio, Spain) (22,25).…”

Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization

“…The use of whole allergen could present the inconvenience of being recognized by specific IgE and then induce asthma rather than treating it. Several studies have already shown the clinical efficacy and safety of allergen-modified extract (allergoids) in asthma (44)(45)(46)(47). Both allergoids and allergen-derived peptides induce Treg and IL-10secreting DCs to reestablish a tolerance defect (48)(49)(50).…”

Microcrystalline Tyrosine and Aluminum as Adjuvants in Allergen-Specific Immunotherapy Protect from IgE-Mediated Reactivity in Mouse Models and Act Independently of Inflammasome and TLR Signaling

“…During processing steps, MCT is either coprecipitated with the candidate Ag or the Ag is adsorbed to the preformed MCT. MCT products are marketed for use in AIT, some of which are licensed ( 15 ), and MCT has been shown to facilitate allergen-specific IgG4 Ab production as well as IL-10 secretion from T cells ( 16 – 19 ). This study compares MCT and alum in mouse models to better understand their mode of action as adjuvants in AIT and other vaccines.…”