2022
DOI: 10.1210/jendso/bvac109
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A Novel Mouse Model to Analyze Non-Genomic ERα Physiological Actions

Abstract: Non-genomic effects of estrogen receptor α (ERα) signaling have been described for decades. Several distinct animal models have been generated previously to analyze the non-genomic ERα signaling (e.g., MOER, ERαC451A). However, the mechanisms and physiological processes resulting solely from non-genomic signaling are still poorly understood. Herein, we describe a novel mouse model for analyzing non-genomic ERα actions named H2NES knock-in (KI). H2NES ERα possesses a nuclear export signal (NES) in the hinge reg… Show more

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Cited by 5 publications
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“…The mouse model with mutated ER α (H2NESKI) exhibits an interesting cardiovascular phenotype where the degree of carotid artery re-endothelialization after electric injury is similar to that of E2-treated wild-type female mice, even in the absence of estrogen by ovariectomy. This observation suggests an intrinsically enhanced non-nuclear ER α signaling in H2NESKI mice ( 93 ).…”
Section: Genetically Modified Animal Models For Er Non-nuclear Signalingmentioning
confidence: 81%
“…The mouse model with mutated ER α (H2NESKI) exhibits an interesting cardiovascular phenotype where the degree of carotid artery re-endothelialization after electric injury is similar to that of E2-treated wild-type female mice, even in the absence of estrogen by ovariectomy. This observation suggests an intrinsically enhanced non-nuclear ER α signaling in H2NESKI mice ( 93 ).…”
Section: Genetically Modified Animal Models For Er Non-nuclear Signalingmentioning
confidence: 81%