A novel multi stimuli-responsive PEGylated hybrid gold/nanogels for co-delivery of doxorubicin and 6‑mercaptopurine

Ghorbani, Marjan; Hamishehkar, Hamed

doi:10.1016/j.msec.2018.07.019

Cited by 43 publications

(9 citation statements)

References 68 publications

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“…Although much progress has been achieved with hydrogels in the biomedical field, their performance could be further improved if their limitations were circumvented. Hydrogels/nanogels were hybridized with other nanomaterials such as magnetic nanoparticles [ 36 , 143 , 144 , 145 ], GNPs [ 146 , 147 , 148 ], and metal-organic frameworks (MOFs) [ 149 ]. Hybridization can impart additional properties, such as multifunctionality [ 149 ] and/or specific stimulus responsiveness [ 52 , 150 , 151 ] to the gel system, thereby improving their performance.…”

Section: Organic Gnp Nanohybrid Chemotherapeutic Platformsmentioning

confidence: 99%

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

et al. 2022

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With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including liposomes and polymers, to achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. The GNP nanohybrids used for targeted chemotherapy can be designed to respond to external stimuli such as heat or internal stimuli such as intratumoral pH. Despite their promise for multimodal cancer therapy, there are currently no reviews summarizing the current status of GNP nanohybrid use for cancer theragnostics. Therefore, this review fulfills this gap in the literature by providing a critical analysis of the data available on the use of GNP nanohybrids for cancer treatment with a specific focus on synergistic approaches (i.e., triggered drug release, photothermal therapy, and radiotherapy). It also highlights some of the challenges that hinder the clinical translation of GNP hybrid nanostructures from bench to bedside. Future studies that could expedite the clinical progress of GNPs, as well as the future possibility of improving GNP nanohybrids for cancer theragnostics, are also summarized.

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Section: Organic Gnp Nanohybrid Chemotherapeutic Platformsmentioning

confidence: 99%

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

et al. 2022

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“…Accordingly, a variety of ROS-stimulusresponsive nanoparticles have been designed to achieve targeted-tissue drug delivery. 15 However, most of the designed sensitive nanodrugs are unstable [16][17][18][19][20][21][22] leading to toxicity in organisms, and also, reducing the accumulation of the drugs within the tumor cells for effective cytotoxicity. 23,24 Therefore, increasing the stability of sensitive nanomedicines in vivo and the concurrent therapeutic effect at the tumor sites remain a conspicuous problem for tumor-microenvironment-sensitive nanomedicines, which needs to be resolved.…”

Section: Introductionmentioning

confidence: 99%

A ROS-Stimulus-Responsive Nanocarrier Loading with Guanidine-Modified Hydroxycamptothecin Prodrug for Enhanced Anti-Tumor Efficacy

Liu

Shen

et al. 2020

CCS Chem

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We report a reactive oxygen species (ROS)stimulus-responsive phenylboronic acid pinacol ester nanocarrier, loaded with guanidine-modified 10-hydroxycamptothecin (HCPT) prodrug, to create a drug delivery-base nanomedicine. The prodrug was stuck tightly in the nanocarrier with over 99% drug-loading efficiency due to the superposition of hydrogen bonds from guanidine and carboxyl, hydrophobic interaction, π-π stacking interaction from phenylboronic acid pinacol ester, and the HCPT prodrug. The aqueous stability of the phenylboronic acid pinacol ester nanocarrier improved remarkably after drug loading because of the interaction between the prodrug and the nanocarrier. Thus, the nanomedicine could realize ROS-triggered disassembly at the tumor sites, release the cell-penetrating prodrug, and achieve improved cellular uptake than the HCPT alone. The results of in vivo antitumor determination demonstrated three-fold inhibition of tumor growth rate of the ROS-stimulus-responsive nanomedicine, compared with HCPT, and the side effects of the prodrug complex reduced significantly. Therefore, our approach offers a promising strategy for the enhancement of antitumor efficacy.

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“…Among them, chemotherapy is a common therapeutic technique for the treatment of numerous cancers. Nevertheless, nonspecific delivery of anticancer agents leads to harmful and adverse side effects on human normal cells and inadequate dosages to kill cancer cells . So, to overcome these problems, nanoscale drug delivery systems (DDS) such as polymeric micelles have achieved remarkable consideration, in the field of cancer therapy because of their self‐assembly ability in the aqueous solvent upon responding to external stimuli initiates, for example, temperature, special enzymes, ionic light, pH, and electric field .…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of gold nanospheres‐cored pH‐sensitive thiol‐ended triblock copolymer: A smart drug delivery system for cancer therapy

Mahmoodzadeh

Hosseinzadeh

Jannat

et al. 2019

Polymers for Advanced Techs

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Conventional chemotherapy suffers lack of multidrug resistance (MDR), lack of bioavailability, and selectivity. Nano‐sized drug delivery systems (DDS) are developing aimed to solve several limitations of conventional DDS. These systems have been offered for targeting tumor tissue owing to enhanced long circulation time, drug solubility, their retention effect, and improved permeability. As a result, the aim of this project was the design and development of DDS for biomedical applications. For this purpose, gold nanospheres (GNSs) covered by pH‐sensitive thiol‐ended triblock copolymer [poly(methacrylic acid) ‐b‐poly(acrylamide) ‐b‐poly(ε‐caprolactone)‐SH; PMAA‐b‐PAM‐b‐PCL‐SH] for delivery of anticancer drug doxorubicin (DOX). The chemical structures of triblock copolymer were investigated by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FTIR) spectroscopies. 1H NMR spectroscopy and gel permeation chromatography (GPC) were used for calculating the molecular weights of each part in the nanocarrier. The success of coating, GNSs with triblock copolymer was considered by means of dynamic light scattering (DLS), FTIR, ultraviolet‐visible (UV‐Vis), and transmission electron microscopy (TEM) measurement. The pH‐responsive drug release ability, (DOX)‐loading capacity, biocompatibility, and in vitro cytotoxicity effects of the nanocarriers were also studied. As a result, it is expected that the synthesized GNSs@polymer‐DOX considered as a potential application in nanomedicine demand like smart drug delivery, imaging, and chemo‐photothermal therapy.

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A novel multi stimuli-responsive PEGylated hybrid gold/nanogels for co-delivery of doxorubicin and 6‑mercaptopurine

Cited by 43 publications

References 68 publications

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy

A ROS-Stimulus-Responsive Nanocarrier Loading with Guanidine-Modified Hydroxycamptothecin Prodrug for Enhanced Anti-Tumor Efficacy

Fabrication and characterization of gold nanospheres‐cored pH‐sensitive thiol‐ended triblock copolymer: A smart drug delivery system for cancer therapy

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