A novel multifunctional carbon aerogel-coated platform for osteosarcoma therapy and enhanced bone regeneration

Dong, Shaojie; Zhang, Yanan; Wan, Jianyu; Cui, Rongrong; Yu, Xingge; Zhao, Guohua; Lin, Kaili

doi:10.1039/c9tb02383f

Cited by 56 publications

(42 citation statements)

References 57 publications

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“…Inorganic biomaterials, including nHA, TCP, bioglass, and bioceramics supply nutrients for tumor-defective bone repair. In a recent study, 111 the surface of beta-tricalcium phosphate bioceramic (β-TCP) materials was coated with carbon aerogel, which was developed for MNNG/HOS osteosarcoma tumor therapy. The carbon aerogel coating particularly enhanced the roughness and surface area of β-TCP, resulting in good bone regeneration in a calvarial defect model.…”

Section: A New Strategy For Tumor Therapy and Bone Regenerationmentioning

confidence: 99%

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

et al. 2021

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Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, surgical resection often fails to completely remove the tumor, which is the main cause of postoperative recurrence and metastasis, resulting in a high mortality rate. Moreover, bone tumors often invade large areas of bone, which cannot repair itself, and causes a serious effect on the quality of life of patients. Thus, bone tumor therapy and bone regeneration are challenging in the clinic. Herein, this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials. Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed. Finally, a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed. This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

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Section: A New Strategy For Tumor Therapy and Bone Regenerationmentioning

confidence: 99%

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

et al. 2021

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“…It was hypothesized that the rough contours on the surfaces were caused by the addition of CS. Studies have been carried out investigating the effects of surface roughness on cellular behavior [ 38 ]. Interestingly, it was reported that the rougher the surfaces, the higher the cellular proliferation and differentiation, due to better cellular adhesion contacts for cells.…”

Section: Resultsmentioning

confidence: 99%

The Development of Light-Curable Calcium-Silicate-Containing Composites Used in Odontogenic Regeneration

et al. 2021

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Pulp regeneration is one of the most successful areas in the field of tissue regeneration, despite its current limitations. The biocompatibility of endodontic biomaterials is essential in securing the oral microenvironment and supporting pulp tissue regeneration. Therefore, the objective of this study was to investigate the new light-curable calcium silicate (CS)-containing polyethylene glycol diacrylate (PEGDA) biocomposites’ regulation of human dental pulp stem cells (hDPSCs) in odontogenic-related regeneration. The CS-containing PEGDA (0 to 30 wt%) biocomposites are applied to endodontics materials to promote their mechanical, bioactive, and biological properties. Firstly, X-ray diffraction and Fourier-transform infrared spectroscopy showed that the incorporation of CS increased the number of covalent bonds in the PEGDA. The diameter tension strength of the CS-containing PEGDA composite was significantly higher than that of normal PEGDA, and a different microstructure was detected on the surface. Samples were analyzed for their surface characteristics and Ca/Si ion-release profiles after soaking in simulated body fluid for different periods of time. The CS30 group presented better hDPSC adhesion and proliferation in comparison with CS0. Higher values of odontogenic-related biomarkers were found in hDPSCs on CS30. Altogether, these results prove the potential of light-curable CS-containing PEGDA composites as part of a ‘point-of-care’ strategy for application in odontogenesis-related regeneration.

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“…Although the Occupational Safety and Health Agency (OSHA) described aerogels as a plausible irritant of the skin and upper airways [ 19 ], epidemiological and mechanistic studies on the plausible health effects of aerogels are scarce. Conversely, hybrid organic–inorganic aerogels are now being considered as a promising agent for targeted drug delivery, wound healing, and bone regeneration [ 35 , 36 , 37 ]. Therefore, whether aerogels impart beneficial or detrimental health effects needs to be understood through properly designed experimental and epidemiological research.…”

Section: Discussionmentioning

confidence: 99%

Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort

Moitra

Tabrizi

Machichi

et al. 2020

IJERPH

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Many insulating materials are used in construction, although few have been reported to cause non-malignant respiratory illnesses. We aimed to investigate associations between exposures to insulating materials and non-malignant respiratory illnesses in insulators. In this cross-sectional study, 990 insulators (45 ± 14 years) were screened from 2011–2017 in Alberta. All participants underwent pulmonary function tests and chest radiography. Demographics, work history, and history of chest infections were obtained through questionnaires. Chronic obstructive pulmonary disease (COPD) was diagnosed according to established guidelines. Associations between exposures and respiratory illnesses were assessed by modified Poisson regression. Of those screened, 875 (88%) were males. 457 (46%) participants reported having ≥ 1 chest infection in the past 3 years, while 156 (16%) were diagnosed with COPD. In multivariate models, all materials (asbestos, calcium silicate, carbon fibers, fiberglass, and refractory ceramic fibers) except aerogels and mineral fibers were associated with recurrent chest infections (prevalence ratio [PR] range: 1.18–1.42). Only asbestos was associated with COPD (PR: 1.44; 95% confidence interval [CI]: 1.01, 2.05). Therefore, occupational exposure to insulating materials was associated with non-malignant respiratory illnesses, specifically, recurrent chest infections and COPD. Longitudinal studies are urgently needed to assess the risk of exposure to these newly implemented insulation materials.

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A novel multifunctional carbon aerogel-coated platform for osteosarcoma therapy and enhanced bone regeneration

Abstract: The implantation of multifunctional carbon aerogel (CA)-coated β-TCP scaffolds for synchronously improving the photothermal ablation and enhanced bone regeneration of osteosarcoma.

Cited by 56 publications

References 57 publications

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

The Development of Light-Curable Calcium-Silicate-Containing Composites Used in Odontogenic Regeneration

Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort

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