A Novel Norditerpenoid from the Okinawan Soft Coral Sinularia Sp.

Bioactive norditerpenoids from the soft coral Sinularia gyrosa

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] A number of these macrocyclic norcembraniods were recently shown to exhibit an array of bioactivities such as antifungal 6 and cytotoxic properties. 6,[10][11][12][13] The continuing search for bioactive constituents urged us to investigate the secondary metabolites of the soft coral Sinularia gyrosa (Tixier-Durivault, 1970), which was collected by hand using SCUBA along the coast of the Dongsha Atoll off Taiwan.…”

Microbial Transformation of 5-Episinuleptolide

“…10) Misinterpretation of the X-ray data and of the configuration at C-11 has led to confusion in the literature, and this error has been propagated in many of the later papers 11,12) and reviews. 13) Sato et al reported the C-11 epimer 14) and Shoji et al reported its C-5 epimer and named it sinuleptolide, 15) hence the name 5-episinuleptolide for compound 1. Recently, Tseng et al isolated and determined unambiguously the absolute configuration of 5-episinuleptolide (1) by a modified Mosher's method as 1R, 5S, 8R, 10S, 11R.…”

Cembrane Diterpenes Chemistry and Biological Properties

“…Gorgonians and soft corals, two groups of coelenterates that belong to the orders Gorgonacea and Alcyonacea respectively, are [45,46,50] Sarcophyton flexuosum 15-17, [11] Sarcophyton stolidotum 372-378 [114] Sarcophyton elegans 18, 19 [12] Sarcophyton cherbonnieri 277, 279, 541 [89] Sarcophyton ehrenbergi 20-23, 204, 205, 263, 542, 543 [13,14] Sarcophyton tortrrosurn 154, 592-594 [58] Sarcophyton tortuosum 585-591 [169,170] Sinularia dissecta 482, 618 [146,176] Sinularia maxima Sinularia polydactyla 516-518, 635-637 [156,180,181] Sinularia maxima 478, 479 [144] Sinularia scabra 507-512 [153][154][155] Sarcophyton crassocaule 440, 441 [17,127,128] Sinularia manaarensis 383-391 [117] Sinularia erecta 498, 500, 609, 610 [151,152] Sinularia leptoclados 491-493 [150] Sinularia lochmodes 496-498, 461 [174,189] Sinularia querciformis 432-435 [126] Sinularia polydactyla 290, 291 [88] Sinularia grandilobata 112-116 [41] [125,150] Sinularia mayi 292-294, 615 [92] Sinularia gyrosaisolated 500-505 [53] Sinularia ovispiculata 56 [26] unidentified soft coral 134-141 [51] Euniceu sp. 52, 58-63, 627-631, 640-644 [24...…”

“…Investigation of the chemical constituents of a Taiwanese soft coral Sinularia scabra has afforded five new norditerpenoids, scabrolides C-G (507-510), which were found to be analogs with those of sinuleptolide (511) and 5-epi-sinuleptolide (512) also isolated previously from the same species and other Sinularia. Metabolite 508 was found to exhibit significant cytotoxicity against the growth of Hepa59T/VGH and KB cell lines (ED 50 's 0.5 and 0.7 μg/mL, respectively) [153][154][155]. Four new norcembrene diterpenolds (513-515) have been isolated from several species of the soft coral Sinularia collected in Palau, Western Caroline Islands [52].…”