This review, with 166 references, covers the literature published on sesterterpenoids together with their relevant biological activities, source organisms and country of origin. The first total syntheses that have led to the revision of structures or stereochemistry have been included.

Starfish have been the research topic in many chemical and pharmacological laboratories due to their complex secondary metabolites and diverse bioactivities. The aim of this review is to provide an up-to-date review on the chemistry and bioactivity of compounds isolated from all kinds of starfish to illustrate the chemodiversity and biological significance of these constituents, along with their geographical distribution where it is discernible.