Chemical Constituents and Bioactivities of Starfish

Dong, Guang‐Hui; Tian, Xu; Yang, Bin; Lin, Xiuping; Zhou, Xuefeng; Yang, Xiong‐Li; Liu, Yonghong

doi:10.1002/cbdv.200900344

Cited by 98 publications

(102 citation statements)

References 213 publications

(295 reference statements)

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“…In addition, our measurements of phosphorus in the sponge D. anchorata, one of the species with lower percentages of P in our study, are similar to the data presented by Hadas et al (2005) for the sponge Negombata magnifica (0.40% dw), a member of Demospongiae sampled in northern Red Sea. According to Dong et al (2011), starfish are rich in phospholipids, which can contribute to explain the high concentration of phosphorus (as well as lipid) found in E. brasiliensis, an animal of moderate mobility.…”

Section: Nitrogen and Phosphorusmentioning

confidence: 99%

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Diniz

Barbarino

Oiano-Neto

et al. 2014

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ABSTRACT. The chemical profiles of Desmapsamma anchorata, Hymeniacidon heliophila (Porifera), Bunodosoma caissarum, Renilla muelleri (Cnidaria), Aplysia brasiliana, Eledone massyae, Isognomon bicolor (Mollusca), Echinaster brasiliensis, Echinometra lucunter, Holothuria grisea, Lytechinus variegatus (Echinodermata), and Phallusia nigra (Chordata) were determined. Hydrosoluble protein was the most abundant class of substances for all species, except for the ascidian Phallusia nigra, in which the carbohydrate content was higher. The percentages of hydrosoluble protein (dry weight, dw) varied widely among the invertebrates, ranging from 5.88% (R. muelleri) to 47.6% (Eledone massyae) of the dw .The carbohydrate content fluctuated from 1.3% (R. muelleri) to 18.4% (Aplysia brasiliana) of the dw. For most of the species, lipid was the second most abundant class of substances, varying from 2.8% (R. muelleri) to 25.3% (Echinaster brasiliensis) of the dw. Wide variations were also found for the invertebrates nitrogen content, with the lowest value recorded in the cnidarian R. muelleri (2.02% of the dw) and the highest in the molluscan E. massyae (12.7% of the dw). The phosphorus content of the dw varyed from 0.24% (R. muelleri) to 1.16% (E. massyae). The amino acid composition varied largely among the species, but for most of the species glycine, arginine, glutamic acid, and aspartic acid were the most abundant amino acids, with histidine and tyrosine among the less abundant amino acids. The actual content of total protein in the samples was calculated by the sum of amino acid residues, establishing dw values that fluctuated from 11.1% (R. muelleri) to 66.7% (E. massyae). The proteinaceous nitrogen content was high in all species, with an average value of 97.3% of the total nitrogen. From data of total amino acid residues and total nitrogen, specific nitrogen-to-protein conversion factors were calculated for each species. The nitrogen-to-protein conversion factors ranged from 5.10 to 6.15, with an overall average of 5.45. The use of the specific nitrogen-to-protein conversion factors established here is recommended, since it would yield more accurate determinations of total protein in the species tested in this study. Keywords: nitrogen-to-protein conversion factors, total protein, amino acid composition, lipid, carbohydrate, tropical Atlantic. Composición proximal de invertebrados marinos de aguas costeras tropicales,con énfasis en la relación entre los contenidos de nitrógeno y proteína RESUMEN. Se determinaron los perfiles químicos de Desmapsamma anchorata, Hymeniacidon heliophila (Porifera), Bunodosoma caissarum, Renilla muelleri (Cnidaria), Aplysia brasiliana, Eledone massyae, Isognomon bicolor (Mollusca), Echinaster brasiliensis, Echinometra lucunter, Holothuria grisea, Lytechinus variegatus (Echinodermata), y Phallusia nigra (Chordata). La clase más abundante de sustancias para todas las especies fueron las proteínas hidrosolubles, excepto para la ascidia Phallusia nigra, en la que el contenido de carbohidratos fue ...

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Section: Nitrogen and Phosphorusmentioning

confidence: 99%

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Diniz

Barbarino

Oiano-Neto

et al. 2014

lajar

View full text Add to dashboard Cite

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“…The toxic potentials of five steroids (1)(2)(3)(4)(5) were evaluated toward the viability of HepG2 and U87MG cells using MTT assay (see Supporting information). As shown in Figure 2(a) and 2(b), cell viability was decreased in a dose-dependent manner after treatment with varying concentration of 4 for 24 h, whereas other steroids had no effect (data not shown).…”

Section: 9mentioning

confidence: 99%

“…2,3 Among marine organisms, the research on starfish has expanded rapidly over the past few years, which has been prompted by the discovery of a variety of unique structures and the interest in their pharmacological properties. 4 Various secondary metabolites including steroids, steroidal glycosides, anthraquinones, alkaloids, phospholipids, peptides, and fatty acids were reported from starfish, in which polyhydroxysteroids are known as the predominant secondary metabolites. 4 In this study, the starfish Ctenodiscus crispatus (Ctenodiscidae family) was collected at the Sea of Okhotsk.…”

Section: Introductionmentioning

confidence: 99%

“…4 Various secondary metabolites including steroids, steroidal glycosides, anthraquinones, alkaloids, phospholipids, peptides, and fatty acids were reported from starfish, in which polyhydroxysteroids are known as the predominant secondary metabolites. 4 In this study, the starfish Ctenodiscus crispatus (Ctenodiscidae family) was collected at the Sea of Okhotsk. Previous investigations on chemical composition of C. crispatus have shown the presence of some polyhydroxylated steroids.…”

Section: Introductionmentioning

confidence: 99%

“…Previous investigations on chemical composition of C. crispatus have shown the presence of some polyhydroxylated steroids. 5,6 As a part of our on-going search for bioactive secondary metabolites from marine organisms, this study describes the isolation and identification of five steroids (1)(2)(3)(4)(5) from the cold water starfish C. crispatus.…”

Section: Introductionmentioning

confidence: 99%

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Steroids from the Cold Water Starfish Ctenodiscus crispatus with Cytotoxic and Apoptotic Effects on Human Hepatocellular Carcinoma and Glioblastoma Cells

Quang¹,

Lee²,

Han³

et al. 2014

Bulletin of the Korean Chemical Society

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Chemical investigation on the methanol extract of the starfish Ctenodiscus crispatus resulted in the isolation of five steroids, (22E,24ξ)-26,27-bisnor-24-methyl-5α-cholest-22-en-3β,5,6β,15α,25-pentol 25-O-sulfate (1), (22E,24R,25R)-24-methyl-5α-cholest-22-en-3β,5,6β,15α,25,26-hexol 26-O-sulfate (2), (28R)- 24-ethyl-5α-cholesta-3β,5,6β,8,15α,28,29-heptaol-24-sulfate (3), (25S)-5α-cholestane-3β,5,6β,15α,16β,26-hexaol (4), and Δ7-sitosterol (5). Their structures were identified by extensive spectroscopic analyses, including 1D, 2D NMR and MS and chemical methods. Compound 4 showed cytotoxicity against human hepatoma HepG2 and glioblastoma U87MG cells via inhibition of cell growth and induction of apoptosis. Induction of apoptosis by 4 was demonstrated by cell death, DNA fragmentation, increased Bax/Bcl-2 protein ratio and the activation of caspase-3, caspase-9 and poly (ADP-ribose) polymerase (PARP).

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Six New Polyhydroxysteroidal Glycosides, Anthenosides S1 – S6, from the Starfish Anthenea sibogae

Kicha

Ivanchina

et al. 2018

Chemistry & Biodiversity

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Six new polyhydroxysteroidal glycosides, anthenosides S1 - S6 (1 - 6), along with a mixture of two previously known related glycosides, 7 and 8, were isolated from the methanolic extract of the starfish Anthenea sibogae. The structures of 1 - 6 were established by NMR and HR-ESI-MS techniques as well as by chemical transformations. All new compounds have a 5α-cholest-8(14)-ene-3α,6β,7β,16α-tetrahydroxysteroidal nucleus and differ from majority of starfish glycosides in positions of carbohydrate moieties at C(7) and C(16) (1 - 4, 6) or only at C(16) (5). The 4-O-methyl-β-d-glucopyranose residue (2) and Δ -cholestane side chain (3) have not been found earlier in the starfish steroidal glycosides. The mixture of 7 and 8 slightly inhibited the proliferation of human breast cancer T-47D cells and decreased the colony size in the colony formation assay.

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Chemical Constituents and Bioactivities of Starfish

Cited by 98 publications

References 213 publications

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Proximate composition of marine invertebrates from tropical coastal waters, with emphasis on the relationship between nitrogen and protein contents

Steroids from the Cold Water Starfish Ctenodiscus crispatus with Cytotoxic and Apoptotic Effects on Human Hepatocellular Carcinoma and Glioblastoma Cells

Six New Polyhydroxysteroidal Glycosides, Anthenosides S1 – S6, from the Starfish Anthenea sibogae

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