The ITER cable-in-conduit conductors (CICCs) are built up from sub-cable bundles, wound in different stages, which are twisted to counter coupling loss caused by time-changing external magnet fields. The selection of the twist pitch lengths has major implications for the performance of the cable in the case of strain sensitive superconductors, i.e. Nb 3 Sn, as the electromagnetic and thermal contraction loads are large but also for the heat load from the AC coupling loss. At present this is a great challenge for the ITER Central Solenoid (CS) CICCs and the solution presented here could be a breakthrough for not only the ITER-CS but also for CICC application in general. After proposing longer twist pitches in 2006 and successful confirmation by short sample tests lateron, the ITER Toroidal Field (TF) conductor cable pattern was improved. As the restrictions for coupling loss are more demanding for the CS conductors than for the TF conductors, it was believed that longer pitches would not be applicable for the conductors in the CS coils. In this paper we explain how with the use of the TEMLOP model and the newly developed models JackPot-ACDC and CORD, the design of a CICC can be improved appreciably, particularly for the CS conductor layout. For the first time a large improvement is predicted not only providing very low sensitivity to electromagnetic load and thermal axial cable stress variations but at the same time much lower AC coupling loss. Reduction of the transverse load and warm-up cool-down degradation can be reached by applying longer twist pitches in a particular sequence for the sub-stages, offering a large cable transverse stiffness, adequate axial flexibility and maximum allowed lateral strand support. Analysis of short sample (TF conductor) data reveals that increasing the twist pitch can lead to a gain of the effective axial compressive strain of more than 0.3 % with practically no degradation from bending. This is probably explained by the distinct difference in mechanical response of the cable during axial contraction for short and long pitches. For short pitches periodic bending in different directions with relatively short wavelength is imposed because of lack of sufficient lateral restraint of radial pressure. This can lead to high bending strain and eventually buckling. Whereas for cables with long twist pitches the strands are only able to react as coherent bundles, being tightly supported by the surrounding strands, providing sufficient lateral restraint of radial pressure in combination with enough slippage to avoid single strand bending along detrimental short wavelengths. Experimental evidence of good performance was already provided with the test of the long pitch TFPRO2-OST2, which is still until today, the best ITER type cable to strand performance ever without any cyclic load (electromagnetic and thermal contraction) degradation. For reduction of the coupling loss, specific choices of the cabling twist sequence are needed with the aim to minimize the area of linked strands an...