A novel nutritional mixture, MBN, prevents memory impairment via inhibiting NLRP3 inflammasome formation in 5xFAD transgenic mice

Kim, Namkwon; Choi, Jin Gyu; Ju, In Gyoung; Ju, Yeon Joo; Yim, Sung Vin; Lee, Jong Kil; Oh, Myung Sook

doi:10.1080/1028415x.2021.1913952

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Caspase 1 and GSDME-N are known to be the important modulator in cell pyroptosis. 29,30 Activation of caspase 1 could lead to the upregulation of GSDME-N. 31,32 Meanwhile, IL-1β and IL-18 are also pyroptosis-related cytokines. 33,34 Consistently, our study revealed that knockdown of hsa_circ_0000729 could induce pyroptosis in NSCLC cells via upregulating cleaved caspase 1, GSDME-N, IL-1β and IL-18.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis

Xie¹,

Ding²,

Xiao³

2021

CMAR

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Section: Discussionmentioning

confidence: 99%

Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis

Xie¹,

Ding²,

Xiao³

2021

CMAR

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“…Thirdly, although there are many new ndings in the correlation analysis between neurotransmitter metabolism indicators obtained from MRS examination and MMSE score or proportion of immune cells, yet the causal relationship between these correlations remains to be clari ed. NLRP3 may play A key role in the induction of IL-1β expression and the onset of AD, and NLRP3 contributes to the formation of aging lesions in the brain of APP/PS-1 transgenic mice [33][34][35], but the direct correlation between the activation of NLRP3 in ammasome and neurotransmitter metabolism remains to be further studied.…”

Section: Discussionmentioning

confidence: 99%

Correlation between abnormal cellular immune and changes of magnetic resonance spectroscopy in patients with Alzheimer's disease

Zeng

Zhang

Liu

et al. 2023

Preprint

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Neuroinflammation in brain and immune-related cells in peripheral blood may be involved in the occurrence and development of Alzheimer’s disease (AD). This study aims to explore the correlation between the abnormality of cellular immune function and the changes of neurotransmitters. 32 AD cases and 40 Vascular dementia (VD ) cases were studied. Lymphocyte subsets in plasma were detected by flow cytometry. IL-1β and caspase-1 were detected by ELISA. NLRP3 was detected by Western blot. N-cetyl aspartate (NAA), creatine (Cr), choline (Cho), and inositol (MI) equivalence in bilateral hippocampi of patients were examined by MRS. Single-factor correlation analysis was conducted between NAA/Cr or MI/Cr and the proportion of T lymphocyte subsets or NK cell subsets. The proportion of T lymphocyte subsets in the AD group was significantly decreased than that in the non-dementia elderly control (UDE) group (P < 0.01). Caspase-1 and IL-1β protein in the AD group were significantly increased. NLRP3 protein in the AD group were significantly increase. In terms of NAA/Cr ratio or NAA/Cr ratio in the AD group was lower than that in UDE group. The NAA/Cr ratio was significantly positively correlated with the MMSE score (r = 0.81, P < 0.01). There was a significant positive correlation between NAA/Cr ratio and T lymphocyte ratio. The NAA/Cr ratio was significantly negatively correlated with the proportion of NK cells in the blood. There was a significant negative correlation between the MI/Cr ratio and the ratio of T cells in the blood. Abnormal neuroimmune function may be involved in the pathogenesis of AD and affect the metabolism of neurotransmitters such as aspartic acid and inositol in the brain of AD patients.

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Section: Discussionmentioning

confidence: 99%

Correlation between Abnormal Cellular Immune and Changes of Magnetic Resonance Spectroscopy in Patients with Alzheimer's Disease

Zeng

Zhang

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

A novel nutritional mixture, MBN, prevents memory impairment via inhibiting NLRP3 inflammasome formation in 5xFAD transgenic mice

Cited by 6 publications

References 29 publications

Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis

Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis

Correlation between abnormal cellular immune and changes of magnetic resonance spectroscopy in patients with Alzheimer's disease

Correlation between Abnormal Cellular Immune and Changes of Magnetic Resonance Spectroscopy in Patients with Alzheimer's Disease

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