A Novel OCT Technique to Measure In Vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and Its Validity in the Diagnosis of Dry Eye

Napoli, Pietro Emanuele; Coronella, Franco; Satta, Giovanni Maria; Zucca, Ignazio Alberto; Fossarello, Maurizio

doi:10.1167/iovs.13-13613

Cited by 24 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We cannot answer whether such phenomena also occurred in the present study, firstly, as no dry eye patients were included in our work, and, secondly, because the typical residence times reported by Napoli et al. () were in the order of 1–5 min, which is considerably earlier than our first postinstillation measurements were performed.…”

Section: Discussionmentioning

confidence: 56%

Effect of hyaluronic acid on tear film thickness as assessed with ultra‐high resolution optical coherence tomography

Kaya

Schmidl

Schmetterer

et al. 2015

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: The aim of this study was to assess the effect of a single drop of hyaluronic acid on tear film thickness (TFT) in healthy subjects. Methods: Sixteen healthy subjects (eight male/eight female) aged between 20 and 36 years were included in this randomized, double-masked placebocontrolled study. One eye received a single dose of hyaluronic acid (Olixia pure â ; Croma Pharma, Korneuburg, Austria) eye drops, and the fellow eye received physiologic saline solution as placebo control. The study eye was chosen randomly. TFT as measured with a custom-built Fourier-domain optical coherence tomography (FD-OCT) system was the main outcome variable and measured before and every 10 min until 1 hr after topical administration. Results: Baseline TFT was 4.8 AE 0.5 lm in the study eye and 5.0 AE 0.4 lm in the control eyes. Hyaluronic acid significantly increased TFT (p = 0.008 versus placebo) with a maximum effect 10 min after instillation (13.9 AE 11.9%). Post hoc analysis revealed that an increase in TFT was seen until 30 min after administration compared to placebo. Data in the placebo group show high reproducibility with an intraclass correlation coefficient of 0.93 and a coefficient of variation of 5.4 AE 3.3%. Conclusion: The data of this study indicate that hyaluronic acid increases TFT for as long as 30 min in healthy subjects. In addition, our data provide evidence that our custom-built OCT system is capable of measuring residence time of lubricants on the ocular surface.

show abstract

Section: Discussionmentioning

confidence: 56%

Effect of hyaluronic acid on tear film thickness as assessed with ultra‐high resolution optical coherence tomography

Kaya

Schmidl

Schmetterer

et al. 2015

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…Assessment of patients' satisfaction with the administered treatment at the end of the study day. Napoli and co-workers observed that topical instillation of sodium carboxymethylcellulose is associated with a two-layered structure in the OCT image (Napoli et al 2014b). In the table, data for strongly agree and agree as well as for disagree and strongly disagree are pooled.…”

Section: Discussionmentioning

confidence: 99%

“…Cyclosporin, for instance, has been shown to increase tear meniscus ). Napoli and co-workers observed that topical instillation of sodium carboxymethylcellulose is associated with a two-layered structure in the OCT image (Napoli et al 2014b). On top of the epithelial surface of the cornea, an outer band with high reflectivity and an inner band with low reflectivity are observed (Napoli et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh‐resolution optical coherence tomography

Woźniak

Schmidl

Bata

et al. 2016

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…As a two-layered structure, the precorneal TF can be easily visualized and studied with OCT over time after an increase of its volume with an enhancer (Figure 4). This approach is useful to measure the adhesive forces between the corneal epithelium and an artificial TF, the sodium carboxymethylcellulose (NaCMC)-based compound [27]. In a vertically oriented ocular surface, the attractive forces that retain tear fluid in opposition to the gravitational forces (under the same environmental and bodily conditions, e.g., blinking) are clearly represented by the adhesive properties of the system.…”

Section: Structure and Appearance Of The Tear Filmmentioning

confidence: 99%

Fourier-Domain OCT Imaging of the Ocular Surface and Tear Film Dynamics: A Review of the State of the Art and an Integrative Model of the Tear Behavior during the Inter-Blink Period and Visual Fixation

Napoli

Nioi

Mangoni

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

In the last few decades, the ocular surface and the tear film have been noninvasively investigated in vivo, in a three-dimensional, high resolution, and real-time mode, by optical coherence tomography (OCT). Recently, OCT technology has made great strides in improving the acquisition speed and image resolution, thus increasing its impact in daily clinical practice and in the research setting. All these results have been achieved because of a transition from traditional time-domain (TD) to Fourier-domain (FD) technology. FD-OCT devices include a spectrometer in the receiver that analyzes the spectrum of reflected light on the retina or ocular surface and transforms it into information about the depth of the structures according to the Fourier principle. In this review, we summarize and provide the state-of-the-art in FD-OCT imaging of the ocular surface system, addressing specific aspects such as tear film dynamics and epithelial changes under physiologic and pathologic conditions. A theory on the dynamic nature of the tear film has been developed to explain the variations within the individual compartments. Moreover, an integrative model of tear film behavior during the inter-blink period and visual fixation is proposed.

show abstract

A Novel OCT Technique to Measure In Vivo the Corneal Adhesiveness for Sodium Carboxymethylcellulose in Humans and Its Validity in the Diagnosis of Dry Eye

Cited by 24 publications

References 35 publications

Effect of hyaluronic acid on tear film thickness as assessed with ultra‐high resolution optical coherence tomography

Effect of hyaluronic acid on tear film thickness as assessed with ultra‐high resolution optical coherence tomography

Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh‐resolution optical coherence tomography

Fourier-Domain OCT Imaging of the Ocular Surface and Tear Film Dynamics: A Review of the State of the Art and an Integrative Model of the Tear Behavior during the Inter-Blink Period and Visual Fixation

Contact Info

Product

Resources

About