A novel oxidative stress marker in acute myocardial infarction; thiol/disulphide homeostasis

Kundi, Harun; Ateş, İhsan; Kızıltunç, Emrullah; Çetın, Mustafa; Çiçekçioğlu, Hülya; Neşeli̇oğlu, Salim; Erel, Özcan; Örnek, Ender

doi:10.1016/j.ajem.2015.06.016

Cited by 184 publications

(181 citation statements)

References 21 publications

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“…32) In fact, similar to previous studies, we found that the native thiol level was decreased whereas the disulfide level and disulfide/total thiol ratio were increased in all study patients as a result of oxidative damage. 30,33,34) Based on these findings, we can speculate that thiol/disulfide homeostasis was also altered in cancer patients during anthracycline therapy.…”

Section: Discussionmentioning

confidence: 99%

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

et al. 2017

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SummaryThe aim of the present study was to evaluate whether the baseline thiol/disulfide state can predict the occurrence of anthracycline induced cardiac toxicity. A total of 186 cancer patients receiving anthracycline (doxorubicin)-based chemotherapy were enrolled. All patients underwent 2-dimensional (2D) speckle tracking echocardiography (STE) to determine their left ventricular ejection fraction (LVEF) and blood samples for measuring thiol forms were obtained before treatment and 4 weeks after completion of the chemotherapy. The mean dose of doxorubicin exposure was 255 ± 39.2 mg/m 2 . Baseline native thiol was found to be lower whereas baseline disulfide and the disulfide/total thiol ratio were found to be higher in patients who had a decrease in LVEF after anthracycline therapy. Also, the amount of decrease in LVEF was well correlated with the delta value of the thiol forms. Logistic regression analysis revealed that changes in BNP and global longitudinal strain (GLS), baseline level of native thiol, disulfide, and the disulfide/total thiol ratio were strong predictors for a decrease in LVEF.The thiol/disulfide pathway may be a factor for predicting chemotherapy-induced cardiac toxicity as one of the oxidative stress mechanisms. (Int Heart J 2017; 58: 69-72)

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Section: Discussionmentioning

confidence: 99%

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

et al. 2017

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“…Dynamic thiol-disulfide homeostasis is implicated in several disorders (27,28). For example, it has been demonstrated that impaired thiol-disulfide balance has been involved in a variety of diseases such as myocardial infarction, preeclampsia, polycystic ovary syndrome, diabetes mellitus, and cancer (29).…”

Section: Discussionmentioning

confidence: 99%

Impaired Thiol-Disulfide Balance in Acute Brucellosis

et al. 2017

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“…(9,14) Also, thiol oxidation has been linked to risk factors of CVD, including aging, smoking, and obesity. (15) A large body of evidence supports the role of oxidative stress in the pathogenesis of HF.…”

Section: Introductionmentioning

confidence: 99%

Serum free thiols in chronic heart failure

Koning

Meijers

Pasch

et al. 2016

Pharmacological Research

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Oxidative stress is a key element of the pathophysiology of heart failure (HF). As free thiols are readily oxidized by reactive oxygen and sulfur species, their circulating level may directly reflect the systemic redox status. This study addresses the role of serum free thiols in chronic HF, which is of particular interest as free thiols are amenable to therapeutic modulation and thus are a potential target for therapy.Free thiols were measured in serum of 101 previously characterized stable chronic HF patients (93% male, age 63.7 ± 10.0 y, left ventricular ejection fraction 34.6 ± 8.2%), adjusted for total serum protein, and subsequently analysed for associations with clinical and outcome parameters.The mean serum free thiol concentration was 3.6 ± 0.5 μM/g protein. Patients with aboveaverage levels were younger, had better renal function, lower levels of NT-proBNP and PTH, and higher levels of cholesterol. Furthermore, above-average levels were associated with favourable disease outcome, i.e. a decreased rehospitalisation rate and increased patient survival (HR 0.27 (95% CI 0.11-0.62), P=0.002) independent of associated clinical parameters, age and PTH. After adjustment for cholesterol or established prognostic factors in HF, eGFR and NT-proBNP the association was no longer significant, suggesting involvement of these variables in a common pathophysiological pathway.This exploratory study demonstrates favourable associations of serum free thiols with markers of HF severity and prognosis as well as disease outcome, which should be further investigated in larger prospective studies. Restoring redox status by therapeutic modulation of free thiols may be a promising strategy to improve disease outcome in CHF.

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A novel oxidative stress marker in acute myocardial infarction; thiol/disulphide homeostasis

Cited by 184 publications

References 21 publications

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

The Role of Thiol/Disulphide Homeostasis in Anthracycline Associated Cardiac Toxicity

Impaired Thiol-Disulfide Balance in Acute Brucellosis

Serum free thiols in chronic heart failure

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