Impaired Thiol-Disulfide Balance in Acute Brucellosis

Kölgelier, Servet; Ergin, Merve; Demir, Lütfi Saltuk; İnkaya, Ahmet Çağkan; Demir, Nazlım Aktuğ; Alışık, Murat; Erel, Özcan

doi:10.7883/yoken.jjid.2016.196

Cited by 16 publications

(23 citation statements)

References 35 publications

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“…Also, thiol levels negatively correlated with the C-reactive protein values and white blood cell counts in tonsillopharyngitis patients 15 . Similarly, Kolgelier et al showed depletion in native and total thiol levels with oxidative stress due to brucellosis infections 13 . Recently, Ayar and colleagues have demonstrated that plasma thiol levels were significantly lower than the control group in children with sepsis 16 .…”

Section: Discussionmentioning

confidence: 92%

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Novel oxidative stress biomarker in sepsis: dynamic thiol-disulfide homeostasis

Kozanhan

Egilmez

Cekmecelioglu

et al. 2020

Cukurova Medical Journal

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ÖzPurpose: The aim of this study was to investigate the relationship between serum dynamic thiol-disulfide homeostasis (TDH) and sepsis, in adult patients. Materials and Methods: In this observational, prospective, case-control study patients (n=44) diagnosed with sepsis compared with ages and gender-matched healthy controls (n=44). Patients were divided into two subgroups (survivors and non-survivors) dependent variable being remaining alive on the 28th day after ICU admission at the follow-up period. TDH parameters measured using a novel automatic and spectrophotometric method and compared statistically. Results: In patients with sepsis, native thiol, total thiol, and disulfide levels were lower than the control group, and this difference was statistically significant. TDH parameters between surviving and non-surviving patients were similar at the sepsis diagnosis. However, significant differences found in native and total thiol levels at followup via repeated measurement analyses on days 3 and 7 in surviving and non-surviving sub-groups. Conclusion: This study showed that impairment in dynamic TDH in adults with sepsis may be related to negative outcomes.Amaç: Bu gözlemsel, prospektif, vaka kontrol çalışmasında erişkin hastalarda serum dinamik Tiyol-Disülfir Homeostazisi (TDH) ile sepsis arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Sepsis tanısı ile alan 44 hasta, yaş ve cinsiyet uyumlu 44 sağlıklı kontrol ile karşılaştırıldı. Hastalar yoğun bakım ünitesi yatışından sonraki 28. günde sağ-kalan ve hayatını kaybedenler olarak 2 gruba ayrıldı. TDH parametreleri yeni, otomatik ve spektrofotometrik bir yöntem kullanılarak ölçüldü ve sonuçlar istatistiksel olarak karşılaştırıldı. Bulgular: Sepsisli hastalarda, nativ tiyol, total tiyol ve disülfit seviyeleri kontrol grubuna göre daha düşük olarak bulundu ve bu fark istatistiksel olarak anlamlı idi. Başlangıç TDH parametreleri sağ-kalan ve hayatını kaybeden hastalar arasındaki benzer bulundu. Ancak sağ kalan ve ex olan hastaların 3 ve 7. günde tekrarlanan TDH ölçümleri (nativ ve toplam tiyol seviyeleri) arasında anlamlı farklar bulundu. Sonuç: Bu çalışma, erişkin sepsis hastalarında dinamik TDH'deki bozulmanın negatif sonuçlara ilişkili olabileceğini göstermiştir.

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Section: Discussionmentioning

confidence: 92%

“…TDH has assessed in several infectious diseases, and the investigation generally indicates that thiol levels decrease due to inflammation [13][14][15] . Kara et al…”

Section: Discussionmentioning

confidence: 99%

Novel oxidative stress biomarker in sepsis: dynamic thiol-disulfide homeostasis

Kozanhan

Egilmez

Cekmecelioglu

et al. 2020

Cukurova Medical Journal

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“…An overproduction of oxidized thiolated proteins signifies oxidative stress [8,20]. Alterations to thiol-based redox systems therefore modulate several pathways and are associated with various diseases [9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Regulation of the thiol-disulfide network is closely related to the alteration of cellular responses [8]. Therefore, thiol-disulfide status has been linked to a growing number of disease pathophysiologies [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Ergin

Aydın

Yurt

et al. 2018

Exp Clin Endocrinol Diabetes

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“…fight. There are very few studies investigating thiol-disulphide balance in infections 6,7 . Contrary to cytokine levels, the effect of ozone on the thiol-disulphide balance has not yet been well-studied in infection models.…”

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confidence: 99%