The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Ergin, Merve; Aydın, Cevdet; Yurt, Emine Feyza; Çakır, Bekir; Erel, Özcan

doi:10.1055/s-0044-100376

Cited by 19 publications

(11 citation statements)

References 29 publications

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“…Authors have demonstrated that NT and TT levels of prediabetes, type 1 and type 2 diabetes mellitus were lower while disulfide levels and disulfide to NT and disulfide to TT ratios were higher in patients compared to healthy volunteers [28][29][30][31][32] Authors have demonstrated that TDH shifted toward disulfide formation in patients with autoimmune subclinical hypothyroidism and thyroid autoantibodies are positively correlated with disulfide to NT ratio [33].…”

Section: Endocrine Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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Section: Endocrine Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…The impairment of dynamic thiol‐disulfide balance has been exhibited in diabetes mellitus, atherosclerosis, osteoarthritis, varicocele, non‐small cell lung cancer in various studies (Devrimsel et al., 2021; Ergin et al., 2020; Gul et al., 2018). These studies show that the balance between thiol and disulphide can contribute to the evaluation of disease processes.…”

Section: Discussionmentioning

confidence: 99%

Total thiol can contribute to differentiating prostate cancer from BPH: Prostate Thiol Index as a new player

Arpa

Şen²,

Eren

et al. 2021

Andrologia

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To assess the distinctiveness of serum native thiol (NT), total thiol (TT) and disulfide (SS) levels in PCa patients, we created a new parameter, prostate thiol index (PTI)[tPSA (TTxPVxAge) −1/2 ]. We determined the performance of the PTI on PCa diagnosis. A total of 107 male patients (PCa:65; BPH:42) who were separated according to their Gleason scores, ISUP grades and EAU risk groups and 20 healthy subjects were included. The performances of the tests were determined. The PCa and BPH groups had lower NT and TT levels and higher SS levels than the control group. PCa patients had higher PTI, tPSA, fPSA, PSAD levels, lower fPSA%, PV and PSA-AV levels than BPH patients. TT, PTI, tPSA, fPSA, fPSA%, PSA-AV, PSAD and PV had significant diagnostic performances. PTI had the highest AUC value and accuracy, PSA-AV had the highest specificity, and fPSA had the lowest sensitivity.

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“…Furthermore, higher level of thiol and lower level of disulfide in the neuropathy group than the retinopathy group revealed that patients with diabetic neuropathy had less oxidative stress than patients with diabetic retinopathy. Ergin et al [ 3 ] reported that thiol/disulfide balance was impaired in type 2 diabetes mellitus cases. Furthermore, they determined disulfide level higher in the group with diabetic complications than the group with no complications.…”

Section: Discussionmentioning

confidence: 99%

The role of protein oxidation in the development of diabetic microvascular complications

Mertoğlu¹

2021

North Clin Istanbul

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OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.

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The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Abstract: A disequilibrium between thiol-disulfide pairs occurs in patients with type 2 diabetes mellitus, and a gradual increase to disulfide levels may contribute to the disease's severity. Deteriorated thiol-disulfide homeostasis may be relevant to the pathophysiology of type 2 diabetes mellitus.

Cited by 19 publications

References 29 publications

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Total thiol can contribute to differentiating prostate cancer from BPH: Prostate Thiol Index as a new player

The role of protein oxidation in the development of diabetic microvascular complications

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