A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery

Yu, Shuai; Zhang, Xiaoyu; Tan, Guoxin; Tian, Long; Liu, Dandan; Liu, Yaxuan; Yang, Xinggang; Pan, Weisan

doi:10.1016/j.carbpol.2016.08.073

Cited by 232 publications

(102 citation statements)

References 59 publications

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“…The latter include aqueous solutions of methylcellulose [6,7], of hydroxypropyl methylcellulose [6,8], of some block copolymers based on polyalkylene glycols, N-substituted polyacrylamides, polyphosphazenes, etc. [9,10]. However, in all these cases the anomaly has a completely different mechanism that is not associated with the polymerization of ions [6,9,11].…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

The rheological anomaly in water-silicate systems: a possible thermodynamic explanation

Maliavski

Zhuravlova²,

Denysiuk

2017

EEJET

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Section: Literature Review and Problem Statementmentioning

confidence: 99%

The rheological anomaly in water-silicate systems: a possible thermodynamic explanation

Maliavski

Zhuravlova²,

Denysiuk

2017

EEJET

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“…Furthermore, GA has been classified as GRAS (generally recognized as safe) by the FDA and has been approved for the use as a food additive (FDA, ). In the past decade, GA‐modified gelatin has been successfully employed as vehicle to control the release of bioactive molecules in pharmaceutical industry (Elzoghby, ; Santoro, Tatara, & Mikos, ; Yu et al, ). Meng and coworkers () reported the GA crosslinking treatment depressed the burst release of gamma‐oxo (1, 1′‐biphenyl)‐4‐butanoic acid (fenbufen) effectively at the initial release stage of d , l ‐lactide‐co‐glycolide/gelatin nanofibrous scaffold.…”

Section: Introductionmentioning

confidence: 99%

Controlled release of methylene blue from glutaraldehyde‐modified gelatin

Zhu

Zhang

et al. 2019

J Food Biochem

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Gelatin has been identified as a valuable material for controlled release of food ingredients because of its highly ramified three‐dimensional network. In the present work, gelatin was further modified with glutaraldehyde (GA) and prepared as microspheres to further improve its control to release of food ingredients. Features (i.e., chemical structures, thermal properties, network structures, and methylene blue (MB) release kinetics) of both the unmodified and GA‐modified gelatin microspheres were investigated. Results showed that the application of GA enhanced the formation of intramolecular and/or intermolecular crosslinking of gelatin and improved its thermal stability. Besides, the release efficiency of MB from the GA‐modified gelatin was less affected by temperature and pH value compared to the unmodified gelatin. Kinetics analysis proved that the release of MB from gelatin followed the first‐order kinetics. Both the release constant (k) of MB and the diffusion coefficient (Da) of GA‐modified gelatin were significantly lower than those of the unmodified gelatin. Practical applications Gelatin is a valuable material for the release control of food ingredients (e.g., oils, vitamins, antioxidants, and flavor compounds) attributes to its highly ramified three‐dimensional network. However, the low mechanical strength of gelatin makes it susceptible to many environmental factors and has restricted its application. In the present work, gelatin was modified by glutaraldehyde (GA). The chemical structure, thermal properties, network structure, and methylene blue release kinetics of the GA‐modified gelatin microspheres were properly investigated. This research proved that GA‐modified gelatin could be a potential carrier for the release control of given food contents in food industry.

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“…CS has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics, such as biocompatibility, biodegradability, antibacterial, nontoxicity, and low cost [11][12][13]. In addition to these advantages, the existence of primary amino (NH 2 ) and hydroxyl (OH) groups in the CS chain facilitates its surface engineering chemical reactions [14].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells

Guo

Qiu

et al. 2019

International Journal of Polymer Science

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Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines. The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT. The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency. Furthermore, cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The present investigation indicated that the positively charged CS-based nanogel could be potentially used as a promising drug delivery system.

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A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery

Cited by 232 publications

References 59 publications

The rheological anomaly in water-silicate systems: a possible thermodynamic explanation

The rheological anomaly in water-silicate systems: a possible thermodynamic explanation

Controlled release of methylene blue from glutaraldehyde‐modified gelatin

Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells

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