IMPORTANCEThe associations of gestational weight gain (GWG) with infant morbidity and mortality are unclear, and the existing recommendations for GWG have not been stratified by the severity of obesity.OBJECTIVES To identify optimal GWG ranges associated with reduced risks of infant morbidity and mortality across maternal body mass index (BMI) categories.
DESIGN, SETTING, AND PARTICIPANTSThis retrospective cohort study used US nationwide, linked birth and infant death data between 2011 and 2015 to assess the associations of GWG in 2.0-kg groups with infant morbidity and mortality and identified optimal GWG ranges associated with reduced risks of both outcomes, using multivariable logistic regression models. Statistical analysis was performed from February 11 to October 14, 2021.EXPOSURE Gestational weight gain equivalent to 40 weeks.
MAIN OUTCOMES AND MEASURESThe 2 main outcomes were (1) significant morbidity of the newborn infant, defined as any presence of assisted ventilation, admission to the neonatal intensive care unit, surfactant therapy, antibiotic therapy, or seizures; and (2) infant mortality younger than 1 year of age (<1 hour, 1-23 hours, 1-6 days, 7-27 days, or 28-365 days after birth).
RESULTSIn this study of 15 759 945 mother-infant dyads, the mean (SD) age of the women was 28.1 (5.9) years. Women gained a mean (SD) of 14.1 (7.3) kg during pregnancy, and the mean (SD) GWG decreased with BMI categories (underweight, 15.
Optical Orthogonal Frequency-Division Multiplexing (O-OFDM) is eminently suitable for mitigating the multi-path and chromatic dispersion in both Visible Light Communications (VLC) and Optical Fiber Communications. We commence our discourse by surveying the conception and historic evolution of O-OFDM designed for both VLC and optical fiber, culminating in the birth of its most flexible design alternative, namely Layered Asymmetrically Clipped Optical OFDM (LACO-OFDM). We demonstrate that it is eminently suitable for intensity-modulation and direct-detection aided optical communication systems and characterize its design flexibility. It is also shown that given its flexibility, it subsumes a wide range of optical OFDM schemes conceived over the past two decades or so. The LACO-OFDM transmitter and receiver designs strike a compelling compromise between the features of the popular Asymmetrically Clipped Optical OFDM (ACO-OFDM) and Direct Current Offset OFDM (DCO-OFDM). The pivotal role of forward error correction (FEC) designs is also surveyed with the objective of striking a coding gain versus complexity trade-off. We conclude by highlighting a suite of promising techniques capable of further improving the system performance, but require further research. The take-away message of the paper crystallized in the associated design guidelines.
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