A novel pH-responsive hollow mesoporous silica nanoparticle (HMSN) system encapsulating doxorubicin (DOX) and glucose oxidase (GOX) for potential cancer treatment

Cheng, Kaiwu; Zhang, Yu; Li, Yaojia; Gao, Zhiguo; Chen, Fanghui; Sun, Kai; An, Peijing; Sun, Chen; Jiang, Yong; Sun, Bai‐Wang

doi:10.1039/c8tb03198c

Cited by 61 publications

(33 citation statements)

References 44 publications

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“…In addition to coating the mesoporous silica with polymers [36,37], other functional materials such as nanoparticles [38,39], and metal-organic frameworks (MOFs) [40], can also improve the controlled release of drugs and be introduced as smart response by compounding with silica. Jia et al fabricated a DOX/HMS@ZIF capsule (DOX = doxorubicin) as drug carrier by coating ZIF on the outer surface of HMS [40].…”

Section: Hollow Mesoporous Structurementioning

confidence: 99%

Hollow structures as drug carriers: Recognition, response, and release

Zhao

Yang

et al. 2021

Nano Res.

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Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.

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Section: Hollow Mesoporous Structurementioning

confidence: 99%

Hollow structures as drug carriers: Recognition, response, and release

Zhao

Yang

et al. 2021

Nano Res.

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“…5 Large pore volumes of hollow nanostructures can be used to incorporate various hydrophobic and hydrophilic drugs and release them in a controlled manner at a particular targeted site. 5,32,33,54 In order to establish the potency of the bowl-shaped particles as an effective drug carrier, we extended our studies towards determining the cellular uptake behaviour of the particles. Cellular uptake experiments were carried out in C6 glial cells.…”

Section: Papermentioning

confidence: 99%

Continuous flow fabrication of Fmoc-cysteine based nanobowl infused core–shell like microstructures for pH switchable on-demand anti-cancer drug delivery

et al. 2021

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“…Of course, there are also some chemotherapeutic drugs that are used directly in combination with starvation therapy, such as CPT, [ 50 ] paclitaxel (PTX), [ 76 ] and DOX. [ 72,77 ] For instance, GOx and the anticancer drug PTX were loaded in a multifunctional mesoporous silica nanoparticle that was coated with poly ( l ‐lysine) and HA for synergistic cancer starvation and chemistry therapy. [ 76 ]…”

Section: Gox‐instructed Cancer Therapiesmentioning

confidence: 99%

Glucose Oxidase‐Related Cancer Therapies

Wang

Yang

Dong

et al. 2020

Advanced Therapeutics

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Glucose oxidase (GOx), which catalyzes the conversion of glucose into gluconic acid and hydrogen peroxide (H 2 O 2) in the presence of oxygen (O 2), has aroused growing interest for cancer therapy. GOx can starve tumor cells to death by depleting glucose, which is very important for their energy supply, and the generated H 2 O 2 is can be used for oxidation therapy. In addition, GOx-catalyzed glucose oxidation exerts a variety of effects on the tumor environment, such as enhancing hypoxia and increasing acidity. The full use of these characteristics can effectively reduce side effects and enhance the therapeutic efficiency of GOx-related cancer therapies. As is generally acknowledged, it is difficult to completely eliminate tumors with a single treatment, whereas combining two or more therapies may yield super-additive results because when properly designed, different treatments can compensate for the shortcomings of the other treatments and bring out the best in each other. In view of these facts, enhanced therapies and combination therapies related to glucose oxidation have been widely studied, and this review provides a systematic overview of recent research on GOx-related cancer therapies (especially starvation therapy) from the perspective of glucose oxidation (including the reaction itself, oxygen, enzymes, gluconic acid, and H 2 O 2) and other combination therapies.

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A novel pH-responsive hollow mesoporous silica nanoparticle (HMSN) system encapsulating doxorubicin (DOX) and glucose oxidase (GOX) for potential cancer treatment

Abstract: The multi-therapy modality is based on the combination and synergy of multiple single treatment modalities and materials chemistry.

Cited by 61 publications

References 44 publications

Hollow structures as drug carriers: Recognition, response, and release

Hollow structures as drug carriers: Recognition, response, and release

Continuous flow fabrication of Fmoc-cysteine based nanobowl infused core–shell like microstructures for pH switchable on-demand anti-cancer drug delivery

Glucose Oxidase‐Related Cancer Therapies

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