A Novel Phorbol Ester from Excoecaria agallocha

Erickson, Karen L.; Beutler, John A.; Cardellina, John H.; McMahon, James B.; Newman, D. J.; Boyd, M R

doi:10.1021/np50119a020

Cited by 68 publications

(50 citation statements)

References 8 publications

(9 reference statements)

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“…12-Deoxyphorbol 13-decadienoate, isolated from Excoecaria agallocha as an anti-HIV principle, was also a potent displacer of [ 3 H]-phorbol dibutyrate from rat brain membrane. 32) However, other derivatives (4, 6) were found to potently inhibit the HIV-1-induced CPE without activating PKC. Kubinski et al 33) reported that although chemically related compounds tend to change the properties of the microsomal membrane in a similar way, TPA (8) decreased the amount of bound DNA 5-fold, while phorbol 12,13-didecanoate, the second strongest promoter, increased this amount by about one-third.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type-1 by Various Phorbol Derivatives.

El‐Mekkawy

Meselhy

Abdel‐Hafez

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Discussionmentioning

confidence: 99%

Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type-1 by Various Phorbol Derivatives.

El‐Mekkawy

Meselhy

Abdel‐Hafez

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The boundless tropical variety Excoecaria is known for the generation of dangerous metabolites [1]. It is appropriated on sea-shores and edge mangroves once in a while developed for wind and ocean softens up tropical Africa and east Asia.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Flavone of Excoecaria agallocha in Cytotoxicity Studies Using Hela Cells

Rajeswari¹,

Rao²,

Sharma³

et al. 2017

Asian J. Chem.

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In this study, the compound flavone of mangrove plant Excoecaria agallocha was subjected to cytotoxicity studies using Hela cells was produced from ATCC, stock cells was cultured in Dulbecco's Modified Eagle medium (DMEM) supplemented with 10 % inactivated fetal bovine serum (FBS), penicillin (100 IU/mL), streptomycin (100 µg/mL) in an humidified atmosphere of 5 % CO2 at 37 ºC until confluent. The cell was dissociated with trypsin phosphate versene glucose (TPVG) solution (0.2 % trypsin, 0.02% EDTA, 0.05 % glucose in PBS). The viability of the cells are checked and centrifuged. Further 50,000 cells/well was seeded in a 96 well plate and incubated for 24 h. At 37 ºC, 5 % CO2 incubator, it was observed that while concentration increases, the inhibition increases. Finally, the compound showing good activity in Hela cells. Docetaxel was used as standard drug.

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“…Clinical trials carried out on this plant showed its potential as anti-HIV, anticancer, antibacterial and antiviral agent (Peter et al, 1999). Previous phytochemical studies on E. agallocha revealed the presence of diterpenoids (ISI database, 2008;Ji-Dong et al, 2007;Li et al, 2007;Wang et al, 2006Kang et al, 2005), triterpenoids (Zou et al, 2006), fl avonoid (Konishi et al, 2003) and phorbole esters (Ericson et al, 1995). As part of our continuing phytochemical and bioactivity studies on Bangladeshi medicinal plants and also in other parts of the world (Alam et al, 2008a,b;Ali et al, 2008;Datta et al, 2007Datta et al, , 2004Saha et al, 2007;Uddin et al, 2007aUddin et al, -c, 2006aUddin et al, ,b, 2005Uddin et al, , 2004Rouf et al, 2006;Haque et al, 2004;Rahman et al, 2004;Delazar et al, 2006;Shoeb et al, 2007;Auzi et al, 2007;Zamani et al, 2007;Razavi et al, 2008), we now report on the neuropharmacological and antibacterial activities, and acute toxicty of the ethanol extract of the bark of E. agallocha in laboratory rodents as well as brine shrimp toxicity.…”

Section: Introductionmentioning

confidence: 99%