A Novel Photocrosslinkable and Cytocompatible Chitosan Coating for Ti6Al4V Surfaces

Zujur, Denise; Moret, Josnell; Rodriguez, Dubrasvka; Cruz, L. Gomes da; Lira, J.; Gil, Linda; Domínguez, E Gutiérrez; Alvarez-Barreto, Jose F.

doi:10.5301/jabfm.5000227

Cited by 4 publications

(19 citation statements)

References 34 publications

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“…Anotherpossiblewayistoincreasethenaturalthickness of TiO 2 is by surface treatments (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Oxidation treatments,specificallyanodization,havebeenconsideredtotune theTiO 2 layerinordertoincreaseitsthicknessandtoobtaina mostlyamorphousphase,withthefinalaimtoincreasepure titaniumcorrosionresistanceuptothelevelofmoreexpensivealloys.Thermaloxidation,chemicaloxidationandionimplantationareotherpossibletechniques.…”

Section: Introductionmentioning

confidence: 99%

Corrosion of Titanium: Part 1: Aggressive Environments and Main Forms of Degradation

Prando

Brenna

Diamanti

et al. 2017

Journal of Applied Biomaterials & Functional Materials

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expanded to other applications, such as power plants, the foodindustry,petrochemicalplants,refineries,heatexchangers,marinestructuresandmedicalprostheses(4,5). Commercially available titanium is classified depending on its purity and elemental composition. The main classification for titanium is provided by the American Society forTestingandMaterials(ASTM).Thefirst4ASTMgradesof titanium are referred to as "commercially pure" and are not alloyed but only present differences in terms of contents of impurities, especially oxygen (6): grade 1 contains a maxi-mumof0.18% oxygen whilegrade4hasamaximumof0.40%.

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Section: Introductionmentioning

confidence: 99%

Corrosion of Titanium: Part 1: Aggressive Environments and Main Forms of Degradation

Prando

Brenna

Diamanti

et al. 2017

Journal of Applied Biomaterials & Functional Materials

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“…The full-text evaluation of screened studies was performed, 88 studies were omitted because of the exclusion criteria listed in the figure. Only 8 studies were finally selected, which satisfied the inclusion criteria [39][40][41][42][43][44][45][46][47]. Furthermore, an additional paper was found whilst hand searching the reference list of the selected studies thoroughly.…”

Section: Resultsmentioning

confidence: 99%

Influence of Chitosan or Keratin on Titanium Implant Surface - A Systematic Review

Love¹,

Ranjit²,

Sharma³

et al. 2020

RGM

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Purpose: This systematic review was carried out to investigate the effects of keratin and chitosan hydrogel preparations on dental implant osseointegration. Materials and Methods: The electronic search was conducted on five databases: Scopus, EBSCOhost MEDLINE, EBSCOhost Dentistry and Oral Science, PubMed, and Web of Science. Studies that determined the in vitro or in vivo efficacy of keratin and chitosan hydrogel on osseointegration were included in the review. Results: Of the 760 studies initially gathered, nine met the inclusion criteria. These studies demonstrated that dental implants coated with keratin and chitosan hydrogels resulted in improved biological properties. It was also concluded that the inclusion of chitosan in keratin hydrogels improves the mechanical strength and helps increase durability through ameliorating degradation and swelling characters. Both the polymers increased bone-implant contact and new bone formation in animal models. Conclusion: This systematic review demonstrates that keratin and chitosan hydrogel, is effective in initiating osteogenesis, reinforcing the currently available evidence that these polymers could be a substrate in dental implant treatment.

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“…Para este proceso se utilizó quitosano con un peso molecular promedio de 4.3x10 5 Da. Esta modificación fue utilizada previamente en nuestro grupo de investigación, demostrando estabilidad del QT modificado luego de ciclos de esterilización, a través de espectroscopia infrarroja por Transformada de Fourier, y resonancia magnética nuclear [2] . La actividad de fosfatasa alcalina se utiliza como un marcador de diferenciación osteogénica temprana [22] .…”

Section: Elaboración De Los Hidrogeles De Quitosano Modificado: Nano-unclassified

“…El tejido óseo presenta una limitada capacidad auto-regenerativa bajo diferentes condiciones, tales como las lesiones de gran tamaño, baja actividad celular, cáncer, y otras patologías. En estas circunstancias, es necesaria la búsqueda de soluciones externas como prótesis e injertos biológico (autoinjertos, aloinjertos y xenoinjertos) [1] , los cuales presentan diferentes limitaciones que abarcan desde la falta de integración con el organismo (osteointegración) hasta los riesgos de rechazo y transmisión de enfermedades [2,3] . La ingeniería de tejidos nace como una alternativa viable, haciendo uso de componentes como células (progenitoras o diferenciadas), factores de crecimiento y diferenciación, y andamios biofuncionales hechos de biomateriales [1,2] .…”

Section: Introductionunclassified

“…Además, incluye, a través del mismo mecanismo, la modificación con ácido azidobenzoico, permitiendo que, bajo una corta exposición bajo luz UV, el QT pueda entrecruzarse y formar hidrogeles tridimensionales estables [11] . El quitosano modificado según este protocolo también ha sido utilizado como base para recubrimientos activos sobre superficies de Ti6Al4V, demostrando capacidad de adhesión y proliferación celular, así como su diferenciación osteogénica [2] .…”

Section: Introductionunclassified

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Mesenchymal Stem Cell Culture on Composite Hydrogels of Hydroxyapatite Nanoparticles and Photo-Crosslinking Chitosan

Alvarez-Barreto

Marquez

Gallardo

et al.

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Chitosan (QT) is a biopolymer that has been used in widely used in bone tissue engineering applications, demonstrating great potential for that purpose. Therefore, the present study aims to develop an in situ crosslinking hydrogel system, composed of chitosan and hydroxyapatite (HAP). Briefly, chitosan was modified, using carbodiimide chemistry, with lactobionic and azidobenzoic acid to make it soluble at physiological pH and photo-crosslinkable, respectively. The modified chitosan was mixed with HAP, in different proportions, and later exposed to UV light, yielding hydrogels. Mesenchymal stem cells, from rat bone marrow, were seeded onto the hydrogels and cultured for 4, 10 and 16 days, under osteogenic and non-osteogenic conditions. Through cell proliferation and alkaline phosphatase activity assays, and confocal microscopy, it was observed that the majority of formulations supported cell adhesion and proliferation, and a significant early osteogenic differentiation in formulations 70:30 and 50:50, QT:HAP. According to these results, the proposed photo-crosslinking system has potential for tissue engineering applications, and further specific studies are proposed for cell differentiation.

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A Novel Photocrosslinkable and Cytocompatible Chitosan Coating for Ti6Al4V Surfaces

Cited by 4 publications

References 34 publications

Corrosion of Titanium: Part 1: Aggressive Environments and Main Forms of Degradation

Corrosion of Titanium: Part 1: Aggressive Environments and Main Forms of Degradation

Influence of Chitosan or Keratin on Titanium Implant Surface - A Systematic Review

Mesenchymal Stem Cell Culture on Composite Hydrogels of Hydroxyapatite Nanoparticles and Photo-Crosslinking Chitosan

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