A novel phthalazine based highly selective chromogenic and fluorogenic chemosensor for Co2+ in semi-aqueous medium: application in cancer cell imaging

Abstract

A new phthalazine based chemosensor was developed for the highly selective and sensitive detection of Co(2+) in the mixed solvent system, CH3CN-H2O (1 : 1, v/v). In the presence of Co(2+), the colour of the solution changed from yellow to green; the absorption maxima of was red-shifted from 383 nm to 435 nm, and the fluorescence of at 550 nm was significantly enhanced. The sensor showed a detection limit down to 25 nM by forming a complex species with Co(2+) in 1 : 1 stoichiometry. Furthermore, by means of confocal laser scanning microscopy experiments, it has demonstrated that it can be used as a fluorescent probe for monitoring Co(2+) in living cells.

Novel Diarylethene-Based Fluorescent Switching for the Detection of Al3+ and Construction of Logic Circuit

“…Phthalazine is a heterocyclic organic compound with two nitrogen atoms. It is considered as one of the crucial sensors and chelating agents for many metal ions, because it could act as the metal-binding group and fluorophore. − Until now, there was no report on the fluorescent switching of diarylethene containing the phthalazine unit.…”

A phthalazine-based two-in-one chromogenic receptor for detecting Co2+and Cu2+in an aqueous environment

“…3,9,16,21,41 In this regard, we expected that the presence of phthalazine and quinoline moieties in a Schiff base might be a good receptor toward the specific transition metal ions by a color change. 24,26,34,[42][43][44] Herein, we report on a new Schiff base chemosensor 1 with both the phthalazine and quinoline groups. The receptor 1 exhibited an exclusive sensing property towards Co 2+ and Cu 2+ via color changes from pale yellow to pink and to orange in a near-perfect aqueous solution.…”

A novel diarylethene‐based fluorescence sensor with a benzohydrazide unit for the detection of Zn2+

“…Upon addition of Zn 2+ , the formation of stable chelate 1o′ leads to the inhibition of CN bond isomerization and enhanced molecular rigidity, which results in the chelated enhanced fluorescence (CHEF) effect and increased emission intensity. [ 65,66 ]…”