A novel phytosterols delivery system based on sodium caseinate-pectin soluble complexes: Improving stability and bioaccessibility

Gan, Caifang; Liu, Qian; Zhang, Ying; Shi, Tianyu; He, Wen‐Sen; Jia, Chengsheng

doi:10.1016/j.foodhyd.2021.107295

Cited by 54 publications

(23 citation statements)

References 46 publications

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“…The literature has reported that diffuse and large peaks in amorphous materials are due to molecules that are disorderly displayed, producing dispersed bands. In contrast, crystalline materials are characterised by sharp and defined peaks because of the highly ordered molecules [ 44 ]. Other lower diffraction peaks were shown at around 38° to 40°, which further affirmed the inexistence of any ordered crystalline structure.…”

Section: Resultsmentioning

confidence: 99%

Micro-Encapsulation of Phytochemicals in Passion Fruit Peel Waste Generated on an Organic Farm: Effect of Carriers on the Quality of Encapsulated Powders and Potential for Value-Addition

2022

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The passion (Passiflora edulis Sims) fruit peel is rich in phenolics and other bioactive compounds and has great potential as a natural food preservative. The present study investigated the value-adding potential of passion fruit peel waste generated on an organic farm. The effect of carriers in encapsulating the peel extract to develop a polyphenolic-rich powder was investigated. The passion fruit peel extracts were prepared using 70% ethanol (1:10 w/v), and encapsulated using waxy starch (WS), gum arabic (GA), and maltodextrin (MT) before freeze-drying. The effects of carriers on the passion fruit peel powder (PFPP) production yield, physicochemical, rheological, phytochemical, and antioxidant properties were investigated. GA-and MT-encapsulated powders had better physical, phytochemical, and antioxidant properties, including yield, total soluble solids, solubility, bulk density, total phenolic content, and ferric reducing antioxidant powder. A total of 18 metabolites, including phenolic acids (10), flavonoids (6), and stilbenes (2), were tentatively identified in all the PFPP samples, with WS exhibiting a higher concentration of the compounds compared to GA and MT. Our results indicated that no single carrier was associated with all the quality attributes; therefore, better results could be produced by compositing these carriers. Nonetheless, our results highlight the potential of passion fruit peels as a source of polyphenols and functional ingredient in formulating natural food additives.

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Section: Resultsmentioning

confidence: 99%

Micro-Encapsulation of Phytochemicals in Passion Fruit Peel Waste Generated on an Organic Farm: Effect of Carriers on the Quality of Encapsulated Powders and Potential for Value-Addition

2022

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“…Therefore, TLH-3/SC PEC NPs significantly improved the in vitro control release of lycopene in the simulated gastrointestinal tract, especially burst releases in SIF. Gan et al also reported that the bioaccessibility of phytosterol encapsulated sodium caseinate (NaCas)/pectin-based phytosterols (NCP-PSs) nanoparticles was increased by at least 43.8% compared to free phytosterols, indicating that the presence of pectin could be adsorbed on the casein micelles by electrostatic interaction and form coating, protecting the nanoparticles from degradation in the gastric environment ( 48 ). A type of lycopene nanoscale liposome carriers (NLCs) was prepared and the adsorption of NLCs in the gastrointestinal wall can prolong the contact time of lycopene with intestinal epithelial cells, thereby increasing the bioavailability of lycopene ( 49 ).…”

Section: Resultsmentioning

confidence: 99%

Biocompatible Polyelectrolyte Complex Nanoparticles for Lycopene Encapsulation Attenuate Oxidative Stress-Induced Cell Damage

Zhang

Jiang²,

Xiang³

et al. 2022

Front. Nutr.

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In this study, lycopene was successfully encapsulated in polyelectrolyte complex nanoparticles (PEC NPs) fabricated with a negatively charged polysaccharide, TLH-3, and a positively charged sodium caseinate (SC) via electrostatic interactions. Results showed that the lycopene-loaded PEC NPs were spherical in shape, have a particle size of 241 nm, have a zeta potential of −23.6 mV, and have encapsulation efficiency of 93.6%. Thus, lycopene-loaded PEC NPs could serve as effective lycopene carriers which affected the physicochemical characteristics of the encapsulated lycopene and improved its water dispersibility, storage stability, antioxidant capacity, and sustained release ability in aqueous environments when compared with the free lycopene. Moreover, encapsulated lycopene could enhance the cells' viability, prevent cell apoptosis, and protect cells from oxidative damage through the Nrf2/HO-1/AKT signalling pathway, via upregulation of antioxidase activities and downregulation of MDA and ROS levels. Therefore, the biocompatible lycopene-loaded PEC NPs have considerable potential use for the encapsulation of hydrophobic nutraceuticals in the food and pharmaceutical industries.

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“…Phytosterols have also been shown to improve the ability of folate-carboxymethyl cellulose nanoparticles to deliver hydrophobic anticancer drugs (doxorubicin) . These edible phytosterols-loaded nanoparticles have great potential for applications in functional foods and pharmaceutical products …”

Section: Delivery Systems For Phytosterolsmentioning

confidence: 99%

“…90 These edible phytosterolsloaded nanoparticles have great potential for applications in functional foods and pharmaceutical products. 91 Before these phytosterols delivery systems can find widespread commercial utilization, there are several issues that need to be addressed. The delivery systems also have some disadvantages that the low encapsulation efficiency of phytosterols, especially the free phytosterols, was more difficult to be loaded than the esterified phytosterols.…”

Section: Delivery Systems For Phytosterolsmentioning

confidence: 99%

Production, Characterization, Delivery, and Cholesterol-Lowering Mechanism of Phytosterols: A Review

Zhang

Han

McClements

et al. 2022

J. Agric. Food Chem.

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Phytosterols are natural plant-based bioactive compounds that can lower blood cholesterol levels and help prevent cardiovascular diseases. Consequently, they are being utilized in functional foods, supplements, and pharmaceutical products designed to improve human health. This paper summarizes different approaches to isolate, purify, and characterize phytosterols. It also discusses the hypolipidemic mechanisms of phytosterols and their impact on cholesterol transportation. Phytosterols have a low water-solubility, poor chemical stability, and limited bioavailability, which limits their utilization and efficacy in functional foods. Strategies are therefore being developed to overcome these shortcomings. Colloidal delivery systems, such as emulsions, oleogels, liposomes, and nanoparticles, have been shown to be effective at improving the water-dispersibility, stability, and bioavailability of phytosterols. These delivery systems can be used to incorporate phytosterols into a broader range of cholesterol-lowering functional foods and beverages. We also discuses several issues that need to be addressed before these phytosterol delivery systems can find widespread commercial utilization.

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A novel phytosterols delivery system based on sodium caseinate-pectin soluble complexes: Improving stability and bioaccessibility

Cited by 54 publications

References 46 publications

Micro-Encapsulation of Phytochemicals in Passion Fruit Peel Waste Generated on an Organic Farm: Effect of Carriers on the Quality of Encapsulated Powders and Potential for Value-Addition

Micro-Encapsulation of Phytochemicals in Passion Fruit Peel Waste Generated on an Organic Farm: Effect of Carriers on the Quality of Encapsulated Powders and Potential for Value-Addition

Biocompatible Polyelectrolyte Complex Nanoparticles for Lycopene Encapsulation Attenuate Oxidative Stress-Induced Cell Damage

Production, Characterization, Delivery, and Cholesterol-Lowering Mechanism of Phytosterols: A Review

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