A Novel Polysaccharide From Chuanminshen violaceum and Its Protective Effect Against Myocardial Injury

Abstract

We isolated and purified a novel polysaccharide from the root of Chuanminshen violaceum, namely, Chuanminshen violaceumis polysaccharide (CVP) and confirmed its structure and molecular weight. Furthermore, in vivo experiment, CVP’s protective effect against myocardial ischemia-reperfusion (I/R) injury in mice was evidenced by significantly reducing I/R-induced myocardial infarction (MI) size, decreasing the secretion of heart damage biomarkers, and improving cardiac function. Then, the myocardial anoxia/reoxygenation (A/R) injury model was established to mimic reperfusion injury. Noticeably, ferroptosis was the major death manner for A/R-damaged H9c2 cells. Meanwhile, CVP significantly inhibited ferroptosis by decreasing intracellular Fe2+ level, enhancing GPX4 expression, and suppressing lipid peroxidation to confront A/R injury. In conclusion, CVP, with a clear structure, ameliorated I/R injury by inhibiting ferroptosis.

Electrospun Chitosan–Polyvinyl Alcohol Nanofiber Dressings Loaded with Bioactive Ursolic Acid Promoting Diabetic Wound Healing

“…Therefore, decreasing ROS levels and suppressing the secretion of inflammatory cytokines are also critical elements for diabetic wound treatment. Recently, some studies demonstrated that introducing bioactive compounds into the electrospun nanofibers that can enhance the anti-inflammatory and anti-oxidant functions of electrospinning-based dressings seems to be a potentially effective route for diabetic wound treatment [ 26 , 27 ]. Philip et al demonstrated that the electrospinning dressing loaded with growth factor TGF-β helped to recruit inflammatory cells to the wound site, deactivated the superoxide ions, and promoted granulation tissue formation [ 28 ].…”