A novel powder coating process for attaining taste masking and moisture protective films applied to tablets

Cerea, Matteo; Zheng, Weijia; Young, Christopher R.; McGinity, James W.

doi:10.1016/j.ijpharm.2004.04.015

Cited by 113 publications

(40 citation statements)

References 9 publications

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“…It is well known that exposure to moisture accelerates the recrystallization process of amorphous drugs and reduces the drug dissolution rate (32). Eudragit® EPO coating has been noted to protect against moisture penetration (23). It is expected in this study that it would decrease the moisture uptake of amorphous prednisone, thereby decreasing the recrystallization process.…”

Section: Coated Mini-tablets Dissolution Profilesmentioning

confidence: 83%

“…Eudragit® EPO, a pH-dependent copolymer, is insoluble at pH above 5 but becomes soluble at pH below 5. Therefore, this polymer has been selected as an appropriate material for taste masking purpose (23,31). Figure 7 shows release behavior of prednisone within coated mini-tablet in both simulated saliva solution (pH= 6.8) and in simulated gastric fluid solution (pH=1.2).…”

Section: Coated Mini-tablets Dissolution Profilesmentioning

confidence: 99%

“…For instance, Eudragit® EPO is a taste-masking and moisture-protective material which has been extensively applied in film coating (23). Since it is a pH-dependent copolymer, it is only slightly swellable when the pH is higher than 5 and is completely soluble when the pH is lower than 5.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Mini-Tablet of Co-Grinded Prednisone–Neusilin Complex for Pediatric Use

et al. 2013

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Abstract. The purpose of this study is to enhance the dissolution rate of prednisone by co-grinding with Neusilin to form a complex that can be incorporated into a mini-tablet formulation for pediatrics. Prednisone-Neusilin complex was co-grinded at various ratios (1:1, 1:3, 1:5, and 1:7). The physicochemical properties of the complex were characterized by various analytical techniques including: differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), scanning electron microscope (SEM), particle size, surface area, solubility, and dissolution rate. The co-grinded prednisone-Neusilin complex (1:7) was blended with other excipients and was formulated into a 2-mm diameter mini-tablet. The minitablets were further evaluated for thickness, weight, content uniformity, and dissolution rate. To improve taste masking and stability, mini-tablets were coated by dip coating with Eudragit® EPO solution. DSC and XRPD results showed that prednisone was transformed from crystalline state into amorphous state after co-grinding with Neusilin. Particle size, surface area, and SEM results confirmed that prednisone was adsorbed to Neusilin's surface. Co-grinded prednisone-Neusilin complex (1:7) had a solubility of 0.24 mg/ mL and 90% dissolved within 20 min as compared to crystalline prednisone which had a solubility of 0.117 mg/mL and 30% dissolved within 20 min. The mini-tablets containing co-grinded prednisoneNeusilin complex (1:7) exhibited acceptable physicochemical and mechanical properties including dissolution rate enhancement. These mini-tablets were successfully dip coated in Eudragit® EPO solution to mask the taste of the drug during swallowing. This work illustrates the potential use of co-grinded prednisone-Neusilin to enhance solubility and dissolution rate as well as incorporation into a mini-tablet formulation for pediatric use.

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Section: Coated Mini-tablets Dissolution Profilesmentioning

confidence: 83%

Section: Coated Mini-tablets Dissolution Profilesmentioning

confidence: 99%

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Development of a Mini-Tablet of Co-Grinded Prednisone–Neusilin Complex for Pediatric Use

et al. 2013

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“…Some coating processes like hotmelting coating (17), compression coating (18,19) and dry powder coating (20,21) have been investigated and widely used within the paint and automobile industries.…”

Section: Discussionmentioning

confidence: 99%

Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Yang

Wang

et al. 2017

BST

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“…Eudragit ® E PO cationic copolymer commonly used as protective coating and film coating to achieve taste masking [40,41]. Eudragit ® RS and RL are water-insoluble swelling polymers [42], they have low and high permeability, respectively, that makes them suitable for time-controlled formulations and their combination allows tailor-made drug release [43].…”

Section: Fig 1 Chemical Structure Of Eudragit ® E (Left) and Eudragimentioning

confidence: 99%

Preparation and investigation of polymethacrylate-based matrix systems

Korbely

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A novel powder coating process for attaining taste masking and moisture protective films applied to tablets

Cited by 113 publications

References 9 publications

Development of a Mini-Tablet of Co-Grinded Prednisone–Neusilin Complex for Pediatric Use

Development of a Mini-Tablet of Co-Grinded Prednisone–Neusilin Complex for Pediatric Use

Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection

Preparation and investigation of polymethacrylate-based matrix systems

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