A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT)

Nackiewicz, Joanna; Kliber-Jasik, Marta; Skonieczna, Magdalena

doi:10.1016/j.jphotobiol.2018.12.002

Cited by 29 publications

(14 citation statements)

References 40 publications

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“…Folate polyethylene glycol- b -poly(asparaginyl-chidamide) (FA-PEG- b -PAsp-chidamide, FPPC) and polyethylene glycol- b -poly(asparaginyl-chidamide) (PEG- b -PAsp-chidamide, PPC) were synthesized as described in supplementary materials referring to literature method 4,24–27. 10 mg FPPC was dissolved in 3 mL of PBS (pH 7.4) and 1 mg Pha in 0.5 mL of THF was immediately added.…”

Section: Methodsmentioning

confidence: 99%

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<p>Folate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy</p>

Ma¹,

Hu²,

Guo³

et al. 2019

IJN

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Background: Nonspecific tumor targeting, potential relapse and metastasis of tumor after treatment are the main barriers in clinical photodynamic therapy (PDT) for cancer, hence, inhibiting relapse and metastasis of tumor is significant issues in clinic. Purpose: In this work, chidamide as a histone deacetylases inhibitor (HADCi) was bound onto a pH-responsive block polymer folate polyethylene glycol- b -poly(aspartic acid) (PEG- b -PAsp) grafted folate (FA-PEG- b -PAsp) to obtain the block polymer folate polyethylene glycol- b -poly(asparaginyl-chidamide) (FA-PEG- b -PAsp-chidamide, FPPC) as multimodal tumor-targeting drug-delivery carrier to inhibiting tumor cell proliferation and tumor metastasis in mice. Methods: Model photosensitizer pyropheophorbide- a (Pha) was encapsulated by FPPC in PBS to form the polymer micelles Pha@FPPC [folate polyethylene glycol- b -poly(asparaginyl-chidamide) micelles encapsulating Pha]. Pha@FPPC was characterized by transmission electron microscope and dynamic light scattering; also, antitumor activity in vivo and in vitro were investigated by determination of cellular ROS level, detection of cell apoptosis and cell cycle arrest, PDT antitumor activity in vivo and histological analysis. Results: With favorable and stable sphere morphology under transmission electron microscope (TEM) (~93.0 nm), Pha@FPPC greatly enhanced the cellular uptake due to its folate-mediated effective endocytosis by mouse melanoma B16-F10 cells and the yield of ROS in tumor cells induced by PDT, and mainly caused necrocytosis and blocked cell growth cycle not only in G2 phase but also in G1/G0 phase after PDT. Pha@FPPC exhibited lower dark cytotoxicity in vitro and a better therapeutic index because of its higher dark cytotoxicity/photocytotoxicity ratio. Moreover, Pha@FPPC not only significantly inhibited the growth of implanted tumor and prolonged the survival time of melanoma-bearing mice due to both its folate-mediated tumor-targeting and selectively accumulation at tumor site by EPR (enhanced permeability and retention)effect as micelle nanoparticles but also remarkably prevented pulmonary metastasis of mice melanoma after PDT compared to free Pha, demonstrating its dual antitumor characteristics of PDT and HDACi. Conclusion: As a folate-mediated and acid-activated chidamide-grafted drug-delivery carrier, FPPC may have great potential to inhibit tumor metastasis in clinical photodynamic treatment for cancer because of its effective and multimodal tumor-targeting performance as photosensitizer vehicle.

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Section: Methodsmentioning

confidence: 99%

“…Photodynamic therapy (PDT) has been widely employed and shown effective modality in treating melanoma, breast cancer, superficial tumors 1–4. Although PDT develops rapidly in recent years, several deficiencies have still hampered the application of PDT in the clinic.…”

Section: Introductionmentioning

confidence: 99%

<p>Folate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy</p>

Ma¹,

Hu²,

Guo³

et al. 2019

IJN

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“…PDT is a minimally invasive technique which has proven to be useful for several types of tumors (Phua et al, ), such as esophageal cancer (Wu, Minamide, & Yano, ), melanoma (Nackiewicz, Kliber‐Jasik, & Skonieczna, ), and multidrug‐resistant breast cancer (Aniogo, Plackal Adimuriyil George, & Abrahamse, ). Moreover, it shows antibacterial potential (Oda et al, ), and may be successfully used in actinic keratoses, benign skin disease (Spring, Rizvi, & Hasan, ) or Condyloma acuminatum (S. Hu et al, ).…”

Section: Main Aspects Of Anticancer Photodynamic Therapymentioning

confidence: 99%

Nanocarriers in photodynamic therapy—in vitro and in vivo studies

Sztandera

Gorzkiewicz

Klajnert‐Maculewicz

2019

WIREs Nanomed Nanobiotechnol

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Photodynamic therapy (PDT) is a minimally invasive technique which has proven to be successful in the treatment of several types of tumors. This relatively simple method exploits three inseparable elements: phototoxic compound (photosensitizer [PS]), light source, and oxygen. Upon irradiation by light with specified wavelength, PS generates reactive oxygen species, which starts the cascade of reactions leading to cell death. The positive therapeutic outcome of PDT may be limited due to several aspects, including low water solubility of PSs, hampering their effective administration and blood circulation, as well as low tumor specificity, inefficient cellular uptake and activation energies requiring prolonged illumination times. One of the promising approaches to overcome these obstacles involves the use of carrier systems modulating pharmacokinetics and pharmacodynamics of the PSs. In the present review, we summarized current in vitro and in vivo studies regarding the use of nanoparticles as potential delivery devices for PSs to enhance their cellular uptake and cytotoxic properties, and thus—the therapeutic outcome of PDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…The use of the above-mentioned photosensitizers also has other disadvantages such as the problem of being excreted very slowly from the human organism. The patient undergoing photodynamic therapy is exposed to several weeks’ sensitivity to the Sun’s rays [ 28 , 29 , 30 , 31 , 32 ]. Most of the complex compounds show low absorption of radiation, therefore, when synthesizing new coordination compounds, ligands are carefully selected, or the existing complex compounds are skillfully modified.…”

Section: Introductionmentioning

confidence: 99%

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

Pobłocki

Drzeżdżon

Kostrzewa

et al. 2021

IJMS

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Photodynamic therapy (PDT) has become an alternative to standard cancer treatment methods such as surgery, chemotherapy and radiotherapy. The uniqueness of this method relies on the possibility of using various photosensitizers (PS) that absorb and convert light emission in radical oxygen-derived species (ROS). They can be present alone or in the presence of other compounds such as metal organic frameworks (MOFs), non-tubules or polymers. The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs. The use of coordination compounds in PDT has a significant impact on the amount ROS generated, quantum emission efficiency (Φem) and phototoxic index (PI). In this review, we will attempt to systematically review the recent literature and analyze the coordination complexes used as PS in PDT. Finally, we compared the anticancer activities of individual coordination complexes and discuss future perspectives. So far, only a few articles link so many transition metal ion coordination complexes of varying degrees of oxidation, which is why this review is needed by the scientific community to further expand this field worldwide. Additionally, it serves as a convenient collection of important, up-to-date information.

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A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT)

Cited by 29 publications

References 40 publications

<p>Folate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy</p>

<p>Folate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy</p>

Nanocarriers in photodynamic therapy—in vitro and in vivo studies

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

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