A novel pseudo simulated moving bed with solvent gradient for ternary separations

Feng, Wei; Li, Min; Feng-mei, Huang; Chen, Mingjie; Jiang, Hua; Zhao, Yongjie

doi:10.1016/j.chroma.2011.03.001

Cited by 26 publications

(5 citation statements)

References 30 publications

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“…During the second step, the feed stream is closed and the unit works as a standard SMB where the less and more retained products are collected at the extract and raffinate ports. The use of two different adsorbents [134], solvent gradient [135] (see also the MCSGP process in Section 2.8), five-section SMB [76], with partial-feed [136], and partial-collecting strategies [77] have also been reported for multicomponent separations using a same unit.…”

Section: Multicomponent Separationsmentioning

confidence: 98%

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Gomes

Rodrigues

2011

Chem Eng & Technol

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This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE® unit is addressed to better exemplify a state-ofthe-art SMB lab-scale process development and demonstration.

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Section: Multicomponent Separationsmentioning

confidence: 98%

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Gomes

Rodrigues

2011

Chem Eng & Technol

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“…Since the first gradient application in conventional four‐zone SMB chromatography was described , many different types of gradient operations have been proposed. These include SMB processes involving supercritical mobile phases , solvent composition modulations , , , and temperature gradients . In practice, not many gradient SMB processes are practically applied because of the difficulty in precisely controlling the travelling gradient profiles.…”

Section: Operating Strategies To Extend the Potential Of Conventionalmentioning

confidence: 99%

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

et al. 2017

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Chromatographic separation with solid stationary and fluid mobile phases is widely used to isolate and purify compounds. One of the most productive improvements in preparative chromatography is the simulated moving bed (SMB) process, which enables continuous feed supply and product removal by periodic operation of a multicolumn to simulate a countercurrent flow between the phases. The SMB process produces high‐purity compounds, even with low selectivity, and offers higher productivity and lower eluent consumption than batch chromatography. Recently, intensive efforts have been made to expand the range of applications through the design, modeling, and optimization of the SMB process to produce advanced operating strategies, which are described and evaluated in this review.

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“…Counter‐current chromatography has also been applied without loading after each switch, such as in a gradient with steady state recycle (GSSR) three‐column process by Silva et al and a pseudo‐SMB process by Wei et al . Both processes were able to perform ternary separations with gradients.…”

Section: The Polishing Stepmentioning

confidence: 99%

Continuous counter‐current chromatography for capture and polishing steps in biopharmaceutical production

Steinebach

Müller‐Späth²,

Morbidelli

2016

Biotechnology Journal

123

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The economic advantages of continuous processing of biopharmaceuticals, which include smaller equipment and faster, efficient processes, have increased interest in this technology over the past decade. Continuous processes can also improve quality assurance and enable greater controllability, consistent with the quality initiatives of the FDA. Here, we discuss different continuous multi-column chromatography processes. Differences in the capture and polishing steps result in two different types of continuous processes that employ counter-current column movement. Continuous-capture processes are associated with increased productivity per cycle and decreased buffer consumption, whereas the typical purity-yield trade-off of classical batch chromatography can be surmounted by continuous processes for polishing applications. In the context of continuous manufacturing, different but complementary chromatographic columns or devices are typically combined to improve overall process performance and avoid unnecessary product storage. In the following, these various processes, their performances compared with batch processing and resulting product quality are discussed based on a review of the literature. Based on various examples of applications, primarily monoclonal antibody production processes, conclusions are drawn about the future of these continuous-manufacturing technologies.

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A novel pseudo simulated moving bed with solvent gradient for ternary separations

Cited by 26 publications

References 30 publications

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

Continuous counter‐current chromatography for capture and polishing steps in biopharmaceutical production

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