A novel quadrupole, quistor, quadrupole tandem mass spectrometer

Kofel, P.; Reinhard, Hans Peter; Schlunegger, U. P.

doi:10.1002/oms.1210260517

Cited by 14 publications

(5 citation statements)

References 14 publications

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“…180 Most hybrid tandem mass spectrometers comprised of beam-type analyzers and ion traps have employed a beam-type analyzer as MS-I. These have included mass filter/ion trap, 328,329,207 mass filter/ion-trap/mass filter, 330 mass filter/collision quadrupole/ion-trap, 331 and sector/iontrap [332][333][334] combinations. The use of a beam type analyzer for MS-I is particularly advantageous for minimizing dynamic range limitations imposed by the ion trap.…”

Section: Hybrid Tandem Mass Spectrometersmentioning

confidence: 99%

Mass Analysis at the Advent of the 21st Century

2001

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There have been many new and exciting developments in mass spectrometer systems in recent years. Many of these developments are being driven by challenges presented by molecular biology. The activity is fueled by resources being devoted to drug development, for example, and other medically and biologically related activities. Progress in these applications will be accelerated by improved sensitivity, specificity, and speed. In mass spectrometry, this translates to greater mass resolving power, mass accuracy, mass-to-charge range, efficiency, and speed. It is safe to say that the demands resulting from current analytical needs are likely to be met to varying degrees but probably not by a single analyzer technology or hybrid instrument. On-line and/or off-line separations and manipulations combined with mass spectrometry will also play increasingly important roles. For any analyzer, or combination of analyzers, to become widely used it must have an important application for which its figures of merit are best suited, relative to competing approaches. The relative cost of competing technologies is also an important factor. The mass filter has seen so much use in the past 30 years because its characteristics best fit a wide range of applications. As an example, biological applications, which are currently driving many instrument development activities in mass spectrometry, demand more information, of higher quality, from less material, faster, and at lower cost. Which technologies will dominate biological applications in the coming years is open to speculation. However, in considering the relative merits of today's dominant mass analyzers, areas of opportunity for improvement are apparent. Furthermore, new and more demanding measurement needs are constantly being recognized that will continue to exercise the creativity of the mass spectrometry community.

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Section: Hybrid Tandem Mass Spectrometersmentioning

confidence: 99%

Mass Analysis at the Advent of the 21st Century

2001

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“…To this end the use of the ion trap with an external ion source seemed particularly interesting, but neither the commercially available instruments6 nor a recently suggested instrumental arrangement7 satisfy all the above requirements: indeed, in both cases the ion source is close to the ion trap entrance cap and consequently diffusion of neutral species from the source into the trap can take place. It is worth‐noting, in this context, the instrumental configurations proposed by Morand et al 8 and Kofel et al 9 (EI–CI source/Q/IT, EI–CI source/Q/IT/Q respectively); a higher selectivity of the reactant ions can be obtained by both these approaches, and differential pumping can exclude the diffusion of neutrals from the source into the trap.…”

Section: Resultsmentioning

confidence: 96%

A new external EI/CI source–ion trap system devoted to the study of ion‐molecule reactions

et al. 2002

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A new instrumental arrangement dedicated to the study of ion-molecule reactions and consists of by an electron impact/chemical ionization source mounted 420 mm away from an ion trap is described. It has been designed and developed to exclude diffusion into the ion trap of the neutral reactants from the EI/CI source and so to avoid undesired side-reactions. Its instrumental parameterization is described and some preliminary results are illustrated that show promise for the successful application of the system to the study of ion-molecule reactions.

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“…The deceleration lens was designed according to Schlunegger and co-workers [25]. This combines decelerating stages with refocusing einzel lens elements to compensate for the increased divergence upon deceleration [26].…”

Section: Deceleration Lens and Ms-iimentioning

confidence: 99%

Novel tandem quadrupole-acceleration-deceleration mass spectrometer for neutralization-reionization studies

Tureček

Shaffer

1992

J. Am. Soc. Mass Spectrom.

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A new tandem mass spectrometer of the quadrupole-acceleration lens-deceleration. lens-quadrupole (QADQ) configuration is described. The instrument is designed for neutralization-reionization studies and consists of a 2000-u quadrupole mass analyzer as MS-I, an acceleration electrostatic lens, a series of three differentially pumped collision cells, and an electrostatic deceleration lens, energy filter, and another 2000-u quadrupole mass analyzer as MS-II. The ion optical system achieves high total ion transmission for 5-9-keV ions. Unit mass resolution in neutralization-reionization mass spectra of aromatic compounds is demonstrated. Mass, kinetic energy, and linked scans at various levels of mass resolution and sensitivity are described.

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A novel quadrupole, quistor, quadrupole tandem mass spectrometer

Cited by 14 publications

References 14 publications

Mass Analysis at the Advent of the 21st Century

Mass Analysis at the Advent of the 21st Century

A new external EI/CI source–ion trap system devoted to the study of ion‐molecule reactions

Novel tandem quadrupole-acceleration-deceleration mass spectrometer for neutralization-reionization studies

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