A novel quantitative microarray antibody capture assay identifies an extremely high hepatitis delta virus prevalence among hepatitis B virus–infected mongolians

Chen, Xiaohua; Oidovsambuu, Odgerel; Liu, Ping; Grosely, Rosslyn; Elazar, Menashe; Winn, Virginia D.; Fram, Benjamin; Zhang, Bo; Dai, Hongjie; Dashtseren, B.; Yagaanbuyant, Dahgwahdorj; Genden, Zulkhuu; Dashdorj, Naranbaatar; Bungert, Andreas; Dashdorj, Naranjargal; Glenn, Jeffrey S.

doi:10.1002/hep.28957

Cited by 90 publications

(90 citation statements)

References 24 publications

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“…In a follow up study, in 75 (61%) of the 123 HBsAg‐positive samples an infection with HDV virus was detected . These results confirm the very high prevalence of HBV/HDV co‐infection amongst the Mongolian population.…”

Section: Discussionsupporting

confidence: 56%

Endemic prevalence of hepatitis B and C in Mongolia: A nationwide survey amongst Mongolian adults

Dashtseren

Bungert²,

Bat-Ulzii³

et al. 2017

Journal of Viral Hepatitis

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In this study, a representative group of Mongolian adults was tested for hepatitis B virus (HBV) and hepatitis C virus (HCV). Screening was conducted at 17 different locations on a randomly sampled group, representing the Mongolian adult population. A total of 1158 adults, 500 (43.1%) men and 659 (56.9%) women were included. The prevalence estimates of HBV and HCV amongst the general Mongolian adult population were found to be 11.1%±1% (SE) and 8.5%±0.7% or 207 418 and 160 228 cases, respectively. For HCV, the majority of cases are concentrated in older age groups with a prevalence of 25.8% amongst those aged 50 years and above, whilst the prevalence of HBV does not vary significantly amongst age groups. For both, HBV and HCV, the data indicate a higher risk of infection and a higher mortality because of the hepatitis amongst men than amongst women. This study represents the first nationwide estimate of the prevalence of HBV in Mongolia and also considered the first for HCV since 2005 and confirm the position of Mongolia as one of the hot-spots of chronic hepatitis infection in the world with about 19.4% of the adult population being infected with either HBV or HCV.

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Section: Discussionsupporting

confidence: 56%

Endemic prevalence of hepatitis B and C in Mongolia: A nationwide survey amongst Mongolian adults

Dashtseren

Bungert²,

Bat-Ulzii³

et al. 2017

Journal of Viral Hepatitis

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“…It can only cause chronic infection by superinfection of HBV carriers and for this reason its epidemiology parallels that of the HBV . Despite the high endemicity of the HBV in Central Asia, the impact of HDV infection in this macro‐area is largely unknown, in contrast to its major medical role in surrounding Iran, Pakistan and Mongolia …”

Section: Introductionmentioning

confidence: 99%

The medical impact of hepatitis D virus infection in Uzbekistan

Khodjaeva¹,

Ibadullaeva²,

Khikmatullaeva³

et al. 2019

Liver International

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Background & Aims The hepatitis B virus (HBV) is endemic in Uzbekistan but the medical impact of infection with the HBV‐dependent hepatitis D virus (HDV) is unknown in the Country. An Hepatology Center was recently established at the Institute of Virology in Tashkent, which has set up a database enlisting patients with chronic viral liver disorders from all over Uzbekistan; it provides an observatory on the current scenario of viral hepatitis in the Country. Methods The prevalence of HBV monoinfection, hepatitis C virus (HCV) infection and HDV superinfection on hepatitis B surface antigen (HBsAg)‐positive cirrhosis was determined in 6589 patients with viral cirrhosis collected in the last 3 years. Results Of 1089, 1150 and 1455 carriers of the HBsAg with cirrhosis recruited in 2016, 2017 and 2018, 834 (76.5%), 926 (80.5%) and 1224 (84%) respectively, had antibody to the HDV. In 2016, 2017 and 2018, the prevalence of HDV infection has been 41%, 45% and 49.1% respectively, largely exceeding the prevalence of HBV monoinfection (12.5%, 11% and 9.3% respectively) and surpassing the prevalence of HCV in 2017 and 2018 (44% and 41.5% respectively). The median age of the patients with HDV cirrhosis was 39 years, distinctly lower than that of HBV and HCV patients (46 and 55). Conclusions Superinfection with the HDV is present in over 80% of the HBsAg‐positive cirrhosis in Uzbekistan. The HDV appears to be the major cause of advanced viral liver disease and of juvenile cirrhosis in the Country.

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“…The couple’s country of origin, Mongolia, is highly endemic for HDV [12], thus it is assumed that the wife has been HBV/HDV co-infected since childhood or as a young adult [13]. Prior to HDV transmission to her spouse, the wife experienced high HDV RNA (≥6 log 10 copies/mL), which likely contributed to liver fibrosis progression and increased infectious risk.…”

Section: Discussionmentioning

confidence: 99%

Transmission of hepatitis D virus between spouses: A longitudinal study of the first reported Canadian case

Osiowy

Andonov

Fonseca

et al. 2017

IDCases

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In chronic hepatitis B (CHB), hepatitis D virus (HDV) superinfection can lead to acute liver failure. The incidence of HDV superinfection is unknown, but is often detected in immigrants from HDV endemic countries. In this report, we characterize long-term clinical and virological outcomes in a hepatitis B virus (HBV) infected carrier before and after HDV superinfection, acquired from their spouse having HBV/HDV co-infection. A 38 year-old Mongolian male with CHB on anti-HBV therapy developed acute liver failure following HDV superinfection. Although he recovered, avoiding the need for liver transplant, HDV serological and molecular markers of infection persisted for the subsequent 16-month follow-up period, suggesting the development of CHB/HDV co-infection. The source of his HDV was from his wife of 10 years, a 34-year old Mongolian female known to have inactive CHB/HDV co-infection but who was not on anti-HBV therapy. Phylogenetic analysis of the complete HDV genome from the couple showed >99% similarity, with post-transmission longitudinal sequence revealing specific nucleotide substitutions between both spouse’s HDV genome sequences. This study highlights the ongoing risk of HDV superinfection due to long-term co-habitation or sexual transmission in CHB patients. The fact that transmission occurred after almost a decade of marriage may be due to host immune or environmental factors that created a more favorable condition for transmission.

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A novel quantitative microarray antibody capture assay identifies an extremely high hepatitis delta virus prevalence among hepatitis B virus–infected mongolians

Cited by 90 publications

References 24 publications

Endemic prevalence of hepatitis B and C in Mongolia: A nationwide survey amongst Mongolian adults

Endemic prevalence of hepatitis B and C in Mongolia: A nationwide survey amongst Mongolian adults

The medical impact of hepatitis D virus infection in Uzbekistan

Transmission of hepatitis D virus between spouses: A longitudinal study of the first reported Canadian case

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