A novel radiographic marker of sarcopenia with prognostic value in glioblastoma

Huq, Sakibul; Khalafallah, Adham M.; Ruiz-Cardozo, Miguel Angel; Botros, David; Oliveira, Leonardo A.P.; Dux, Hayden; White, Taija; Jimenez, Adrian E.; Gujar, Sachin K.; Sair, Haris I.; Pillai, Jay J.; Mukherjee, Debraj

doi:10.1016/j.clineuro.2021.106782

Cited by 25 publications

(32 citation statements)

References 36 publications

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“…Our study also shows that although the average TMT value of male patients (0.58 mm) is significantly higher than that of female patients (0.52 mm), the median survival time of female patients (39 months) is significantly lower than that of male patients (45 months). However, gender is not an important factor in the death of related patients, which means that the predictive effect of TMT on the prognosis of AIS patients has nothing to do with gender, which is mutually confirmed with the study by Huq et al [29]…”

Section: Discussionsupporting

confidence: 72%

Long-term prognostic significance of sarcopenia in acute ischemic stroke

Hou

Liu

2022

Medicine

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Because sarcopenia is widely distributed in patients with acute ischemic stroke (AIS) and has not attracted enough attention, this study aims to explore the relationship between sarcopenia defined by temporal muscle thickness (TMT) and physical function and prognosis of patients with AIS. A total of 265 hospitalized nonsurgical AIS patients from 2015 to 2018, with an age range of 28 ~ 92, were analyzed retrospectively. The median value of TMT was used as the risk classification index of sarcopenia. The main results were the relationship between sarcopenia and Essen Stroke Risk Score, National Institutes of Health Stroke Scale, modified Rankin Score, water swallow test, venous thromboembolism assessment of medical inpatients, activities of daily living assessed by Barthel Index, and the relationship between TMT and final survival outcome. The mean TMT of men in the study cohort was higher than that of women. The measured values of TMT among different researchers had good consistency (intraclass correlation coefficient, 0.980; P < .001). After adjusting for confounding variables, logistic regression showed that sarcopenia was associated with Essen Stroke Risk Score (odds ratio, 1.89; P < .05) and Barthel Index (odds ratio, 1.67; P < .05). Kaplan-Meier analysis showed that the survival time of low TMT group was significantly lower than that of high TMT group (36 vs 49 months; P < .001). Multivariate Cox regression showed that there was causal correlation between sarcopenia and patient death (hazard ratio, 3.54; 95% confidence interval, 1.46–8.58; P < .01). As a potential comprehensive index, thickness of temporal muscle can be included in baseline evaluation to show the physical status, stroke recurrence, and survival prognosis of AIS patients.

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Section: Discussionsupporting

confidence: 72%

Long-term prognostic significance of sarcopenia in acute ischemic stroke

Hou

Liu

2022

Medicine

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“…Since this report, there have been several papers on the temporalis muscle and prognosis, especially in brain tumors. There are several reports on overall survival and temporal muscle in glioblastoma [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], metastatic brain tumor [ 31 , 46 , 47 ], and primary central nervous system lymphoma [ 37 , 48 ]. As in reports on TMT and stroke, all of these reports used temporal muscle to indicate nutritional status and skeletal muscle mass volume.…”

Section: Discussionmentioning

confidence: 99%

Temporal Muscle and Stroke—A Narrative Review on Current Meaning and Clinical Applications of Temporal Muscle Thickness, Area, and Volume

et al. 2022

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Background: Evaluating muscle mass and function among stroke patients is important. However, evaluating muscle volume and function is not easy due to the disturbances of consciousness and paresis. Temporal muscle thickness (TMT) has been introduced as a novel surrogate marker for muscle mass, function, and nutritional status. We herein performed a narrative literature review on temporal muscle and stroke to understand the current meaning of TMT in clinical stroke practice. Methods: The search was performed in PubMed, last updated in October 2021. Reports on temporal muscle morphomics and stroke-related diseases or clinical entities were collected. Results: Four studies reported on TMT and subarachnoid hemorrhage, two studies on intracerebral hemorrhage, two studies on ischemic stroke, two studies on standard TMT values, and two studies on nutritional status. TMT was reported as a prognostic factor for several diseases, a surrogate marker for skeletal muscle mass, and an indicator of nutritional status. Computed tomography, magnetic resonance imaging, and ultrasonography were used to measure TMT. Conclusions: TMT is gradually being used as a prognostic factor for stroke or a surrogate marker for skeletal muscle mass and nutritional status. The establishment of standard methods to measure TMT and large prospective studies to further investigate the relationship between TMT and diseases are needed.

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“…On the other hand, chronologic age provides less of a clear algorithmic delineation as the health status of the older adults varies considerably. Certain measures of biological age such as sarcopenia are being investigated as prognostic measures for glioblastoma, and preliminary investigations have suggested correlation with KPS in patients with progressive disease [ 87 ]. As discussed however, currently used performance status metrics of KPS and ECOG-PS are crude measures of fitness and are not necessarily appropriate for GBM patients.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Older Adult Patients with Glioblastoma: Moving towards the Inclusion of a Comprehensive Geriatric Assessment for Guiding Management

Chahal¹,

Thiessen²,

Mariano³

2022

Current Oncology

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Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, and over half of patients with newly diagnosed GBM are over the age of 65. Management of glioblastoma in older patients includes maximal safe resection followed by either radiation, chemotherapy, or combined modality treatment. Despite recent advances in the treatment of older patients with GBM, survival is still only approximately 9 months compared to approximately 15 months for the general adult population, suggesting that further research is required to optimize management in the older population. The Comprehensive Geriatric Assessment (CGA) has been shown to have a prognostic and predictive role in the management of older patients with other cancers, and domains of the CGA have demonstrated an association with outcomes in GBM in retrospective studies. Furthermore, the CGA and other geriatric assessment tools are now starting to be prospectively investigated in older GBM populations. This review aims to outline current treatment strategies for older patients with GBM, explore the rationale for inclusion of geriatric assessment in GBM management, and highlight recent data investigating its implementation into practice.

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A novel radiographic marker of sarcopenia with prognostic value in glioblastoma

Cited by 25 publications

References 36 publications

Long-term prognostic significance of sarcopenia in acute ischemic stroke

Long-term prognostic significance of sarcopenia in acute ischemic stroke

Temporal Muscle and Stroke—A Narrative Review on Current Meaning and Clinical Applications of Temporal Muscle Thickness, Area, and Volume

Treatment of Older Adult Patients with Glioblastoma: Moving towards the Inclusion of a Comprehensive Geriatric Assessment for Guiding Management

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