A novel, rapid and green method of phosphorylation under ultrasound irradiation and catalyst free conditions

Abstract

Phosphorylation of N-acylamines, N-acylaminoesters, N-acylaminoalcohols and N-acylsulfonamides with trialkylphosphite was promoted under ultrasound irradiation using solvent and catalyst free conditions to afford amidophosponates with 75–90% yield in 5–15 min.

Recent Advances in the Synthesis of α‐Aminophosphonates: A Review

“…In the last example, [95] α ‐ureidophosphonates were synthesized via a one‐pot reaction of diverse aromatics aldehydes, urea/thiourea and triethyl or diethyl phosphite with ultrasonic irradiation.…”

Cyclic N‐2‐Chloroethyl‐sulfamide Compounds with a Phosphonate Moiety: Synthesis, Characterization, X‐Ray Crystallographic Study and Antimicrobial Evaluation

“…In 2017, Bouzina and co-workers [27] realised the phosphorylation of a series of N-acylsulfonamides with trimethylphosphite under US conditions and this process provided the expected compounds in [6][7][8][9][10][11][12] minutes with a good yields [84-90]% (Figure 2, compounds 7). If we considered the concomitant role of cyclosulfamide and phosphonate groups in a single molecule, only few syntheses are reported in the literature.…”

A greener procedure for the synthesis of α-ureidophosphonates under ultrasound irradiation. An X-ray crystallographic study

“…On the other hand, one of the powerful tools used to connect economic features with the green concerns is performing organic reactions under ultrasound irradiation [19][20][21][22][23] and solvent-free conditions. [24][25][26][27] This powerful technique became extremely efficient and attractive in synthetic organic chemistry, and is able to activate many reactions due to cavitational collapse. Ultrasound irradiation provides higher yields and selectivities, shorter reaction times and milder reaction conditions, nontoxic, environmentally friendly solvent, in a onestep reaction, without isolation of any intermediate thus reducing time, saving money, energy and raw materials.…”