2022
DOI: 10.1186/s12967-022-03374-y
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A novel rat model for cerebral venous sinus thrombosis: verification of similarity to human disease via clinical analysis and experimental validation

Abstract: Background Cerebral venous sinus thrombosis (CVST) is a rare neurovascular disorder with highly variable manifestations and clinical courses. Animal models properly matched to the clinical form of CVST are necessary for elucidating the pathophysiology of the disease. In this study, we aimed to establish a rat model that accurately recapitulates the clinical features of CVST in human patients. Methods This study consisted of a clinical analysis and … Show more

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Cited by 8 publications
(6 citation statements)
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“…Corresponding to these most common ways of treating CVST, chemical thrombolysis, and mechanical thrombectomy is favorable to be used in severe stage. [16]…”
Section: Cvst Versus Rcvsmentioning
confidence: 99%
“…Corresponding to these most common ways of treating CVST, chemical thrombolysis, and mechanical thrombectomy is favorable to be used in severe stage. [16]…”
Section: Cvst Versus Rcvsmentioning
confidence: 99%
“…In contrast, thread‐embolism models (silicone, plastic) consist in a transient occlusion of the SSS 46–48 . These models allow studying mechanisms involved during occlusion and recanalization (after thread removal) while potentially varying the occlusion time.…”
Section: Rodent Models Of Cvstmentioning
confidence: 99%
“…In the acute phase, Bederson scale and rotarod test have been commonly used to assess neurological functions. However, they could be less sensitive than implementation of different sensorimotor tests to detect slight neurological impairment 26,35,37,48,53 . In contrast, long‐term models of CVST are rarely implemented, and data on the assessment of neurological function are therefore limited 33,41,46 .…”
Section: Relevant Endpoints For Cvst Modelsmentioning
confidence: 99%
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