A novel ratiometric electrochemical assay for ochratoxin A coupling Au nanoparticles decorated MoS2 nanosheets with aptamer

Wang, Yonghong; Ge, Ning; Bi, Hao; Wu, Yaohui; Liu, Gao-Qiang; Zhao, Yunlin

doi:10.1016/j.electacta.2018.07.195

Cited by 40 publications

(22 citation statements)

References 45 publications

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“…MNPs have been employed as transducer surface modifiers to both enhance the capacity for the stable and well-oriented immobilization of biomolecules and improve the charge transport rates [ 6 ]. Taking advantage of these properties, a variety of electrode scaffolds using MNPs have been designed for the construction of enzyme biosensors [ 7 , 8 , 9 , 10 ], immunosensors [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], aptasensors [ 26 , 27 , 28 , 29 , 30 , 31 ], and DNA biosensors [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Table 1 summarizes the main characteristic, including the nanomaterial roles, the limits of detection, and the analyzed sample, of the electrochemical biosensing strategies involving multifunctional MNPs.…”

Section: Multifunctional Metal-based Nanomaterialsmentioning

confidence: 99%

Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

et al. 2020

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Multifunctional nanomaterials, defined as those able to achieve a combined effect or more than one function through their multiple functionalization or combination with other materials, are gaining increasing attention in the last years in many relevant fields, including cargo targeted delivery, tissue engineering, in vitro and/or in vivo diseases imaging and therapy, as well as in the development of electrochemical (bio)sensors and (bio)sensing strategies with improved performance. This review article aims to provide an updated overview of the important advances and future opportunities exhibited by electrochemical biosensing in connection to multifunctional nanomaterials. Accordingly, representative aspects of recent approaches involving metal, carbon, and silica-based multifunctional nanomaterials are selected and critically discussed, as they are the most widely used multifunctional nanomaterials imparting unique capabilities in (bio)electroanalysis. A brief overview of the main remaining challenges and future perspectives in the field is also provided.

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Section: Multifunctional Metal-based Nanomaterialsmentioning

confidence: 99%

Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

et al. 2020

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“…In addition, high concentrations of OTA has certain hepatotoxicity. During the last 5 years, several 2D nanomaterial-based electrochemical biosensors including immunosensors and aptasensors have also been developed for sensing OTA [118][119][120][121][122][123][124][125][126][127][128][129][130][131]. For instance, a series of aptasensors based on rGO-AuNP nanocomposites have been constructed by Wang's group [118][119][120].…”

Section: Ochratoxinmentioning

confidence: 99%

“…The analytical reliability of the amperometric aptasensor has been demonstrated by the detection of OTA in spiked corn samples. Recently, Wang et al constructed a ratiometric electrochemical aptasensor for OTA detection through assembly of a methylene blue (MB)-modified OTA aptamer (MB-aptamer) on the MoS 2 nanosheet/AuNP (MoS 2 -AuNP) nanocomposite-decorated gold electrode through the host-guest recognition of β-cyclodextrin (β-CD) (as shown in Figure 5) [128]. After interaction with OTA, the MB-aptamer was disassembled because of G-quadruplex formation, leading to a decrease in the peak current of MB.…”

Section: Ochratoxinmentioning

confidence: 99%

“…The practicability of the aptasensor was successfully demonstrated by detecting OTA in red wine samples. AuNP) nanocomposite-decorated gold electrode through the host-guest recognition of βcyclodextrin (β-CD) (as shown in Figure 5) [128]. After interaction with OTA, the MB-aptamer was disassembled because of G-quadruplex formation, leading to a decrease in the peak current of MB.…”

Section: Ochratoxinmentioning

confidence: 99%

“…Schematic representation of the fabrication of the ratiometric electrochemical aptasensor for OTA detection based on nanocomposites of gold nanoparticle and MoS 2 nanosheets with β-CD-SH (thiolated β-CD) (adapted from Wang et al 2018[128], Copyright 2018 Elsevier Ltd. and reproduced with permission).…”

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confidence: 99%

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Two-Dimensional Layered Nanomaterial-Based Electrochemical Biosensors for Detecting Microbial Toxins

Jian

et al. 2019

Toxins

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Toxin detection is an important issue in numerous fields, such as agriculture/food safety, environmental monitoring, and homeland security. During the past two decades, nanotechnology has been extensively used to develop various biosensors for achieving fast, sensitive, selective and on-site analysis of toxins. In particular, the two dimensional layered (2D) nanomaterials (such as graphene and transition metal dichalcogenides (TMDs)) and their nanocomposites have been employed as label and/or biosensing transducers to construct electrochemical biosensors for cost-effective detection of toxins with high sensitivity and specificity. This is because the 2D nanomaterials have good electrical conductivity and a large surface area with plenty of active groups for conjugating 2D nanomaterials with the antibodies and/or aptamers of the targeted toxins. Herein, we summarize recent developments in the application of 2D nanomaterial-based electrochemical biosensors for detecting toxins with a particular focus on microbial toxins including bacterial toxins, fungal toxins and algal toxins. The integration of 2D nanomaterials with some existing antibody/aptamer technologies into electrochemical biosensors has led to an unprecedented impact on improving the assaying performance of microbial toxins, and has shown great promise in public health and environmental protection.

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Recent Advances in Electrochemical Sensors for Mycotoxin Detection in Food

Chen

Tang

et al. 2021

Electroanalysis

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Mycotoxins pose a grave global threat to human life and health by contaminating food and feed and cause enormous losses in healthcare and trading. Trace mycotoxin concentrations and diverse matrices in food make identification and measurement challenges, necessitating highly specific and sensitive detection methods. Electrochemical (EC) sensors are characterized by simple operation, outstanding sensitivity, low cost, and facile miniaturization and have become a promising strategy for addressing specificity and sensitivity in detection. Recent studies on EC sensors for mycotoxin detection for food safety are reviewed here. First, we summarize the fabrication of EC sensors and techniques with enhanced specificity and sensitivity. Then, we review state‐of‐the‐art EC sensors for detecting major mycotoxins. Challenges and opportunities for this technology are further discussed. Finally, in‐depth information is provided on using EC sensors to detect mycotoxins for food safety, as well as the development of EC sensors for academic study and practical application.

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A novel ratiometric electrochemical assay for ochratoxin A coupling Au nanoparticles decorated MoS2 nanosheets with aptamer

Cited by 40 publications

References 45 publications

Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

Two-Dimensional Layered Nanomaterial-Based Electrochemical Biosensors for Detecting Microbial Toxins

Recent Advances in Electrochemical Sensors for Mycotoxin Detection in Food

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