“…In RIE/GPRP-R cells, BBSmediated transcriptional induction of the Cox-2 gene is also calcium dependent, requiring activation of components of the AP-1 transcription factor complex, such as Fos/Jun proteins (Guo et al, 2001). Moreover, involvement of Gaq-coupled receptors as the GRP-R in the activation of NFAT and in the induction of NFATdependent genes has been described in a variety of cell types (Boss et al, 1996;Horsley and Pavlath, 2002;Liu et al, 2004). Noticeably, recent reports have proposed that NFAT proteins may play an important role in cancer, having shown a direct involvement of NFATmediated transcriptional regulation of different genes, including Cox-2 (Jauliac et al, 2002;Lara-Pezzi et al, 2002;Saurin et al, 2002;Neal and Clipstone, 2003;Holzmann et al, 2004;Yiu and Toker, 2006).…”