A novel scalable fabrication process for the production of dissolving microneedle arrays

Chen, Hangping; Wu, Biyuan; Yang, Peipei; Yang, Baofeng; Qin, Wanbing; Wang, Qingqing; Wen, Xinguo; Chen, Meiwan; Quan, Guilan; Pan, Xin; Wu, Chuanbin

doi:10.1007/s13346-018-00593-z

Cited by 35 publications

(15 citation statements)

References 22 publications

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“…For scale-up fabrication, several novel techniques have been designed to manufacture dissolving MNs in a highly effective, controllable, and scalable way 78 . The double-penetration female mold-based positive-pressure microperfusion technique was also developed by our group 79 for scale-up fabrication of dissolving MNs 79 .…”

Section: Representative Types Of Mnsmentioning

confidence: 99%

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

Liu

Chen

et al. 2021

Acta Pharmaceutica Sinica B

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Proteins and peptides have become a significant therapeutic modality for various diseases because of their high potency and specificity. However, the inherent properties of these drugs, such as large molecular weight, poor stability, and conformational flexibility, make them difficult to be formulated and delivered. Injection is the primary route for clinical administration of protein and peptide drugs, which usually leads to poor patient's compliance. As a portable, minimally invasive device, microneedles (MNs) can overcome the skin barrier and generate reversible microchannels for effective macromolecule permeation. In this review, we highlighted the recent advances in MNs-mediated transdermal delivery of protein and peptide drugs. Emphasis was given to the latest development in representative MNs design and fabrication. We also summarize the current application status of MNs-mediated transdermal protein and peptide delivery, especially in the field of infectious disease, diabetes, cancer, and other disease therapy. Finally, the current status of clinical translation and a perspective on future development are also provided.

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Section: Representative Types Of Mnsmentioning

confidence: 99%

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

Liu

Chen

et al. 2021

Acta Pharmaceutica Sinica B

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“…One is to improve the efficiency of the traditional degassing method, such as vacuum and centrifugation. For instance, Chen et al developed a novel double-penetration female mold (DPFM) with the pinpoints covered by an air-permeable and hydrophobic membrane, thereby reducing gas resistance and conducting uniformly distributed MNs [86]. The base-to-tip gas exhaust and solution pouring were achieved synchronously, which was favorable in degassing.…”

Section: Micromoldingmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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“…[17] The flow chart is sketched as shown in Figure 2. Laser writing of the acrylic substrate using a CO 2 laser created 3D conical stamps.…”

Section: Industrial or Handmade Manufacture?mentioning

confidence: 99%

“…Another new replica molding–based process was proposed by Chen et al. for the scalable production of dissolving microneedle arrays . The flow chart is sketched as shown in Figure .…”

Section: Industrial or Handmade Manufacture?mentioning

confidence: 99%

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Dardano

Battisti²,

Rea

et al. 2019

Advanced Therapeutics

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Mainly designed and realized as a painless alternative to the hypodermic syringe, microneedle-based devices are currently approaching commercial market placement. The considerable academic and industrial investment in this technology is reflected by a multitude of papers published and patents registered every year, which is also a sign of a field in full fermentation. New materials and innovative methodologies are continuously exploited in search of the best performance at the lowest cost. For these reasons, an updated review, focused predominantly on the last year of scientific production, is a useful guideline in this rapidly changing panorama. This report provides a critical review of microneedle technologies presented in the very recent literature with a particular focus on those closest to the needs of the healthcare field. Although a few devices are already commercial, further effort is still needed to achieve complete clinical translation and therapeutic efficacy competitive with or superior to those of the devices used as standards and adopted by national health systems.

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A novel scalable fabrication process for the production of dissolving microneedle arrays

Cited by 35 publications

References 22 publications

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

Engineering Microneedles for Therapy and Diagnosis: A Survey

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

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