A novel self-powered and sensitive label-free DNA biosensor in microbial fuel cell

Asghary, Maryam; Raoof, Jahan Bakhsh; Rahimnejad, Mostafa; Ojani, Reza

doi:10.1016/j.bios.2016.04.023

Cited by 27 publications

(6 citation statements)

References 21 publications

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“…In 2016, Raoof and co‐workers from University of Mazandaran and Babol Noshirvani University of Technology in Iran reported an electrochemical self‐powered label‐free DNA biosensor based on a dual‐chambered microbial BFC . The anode was a bare graphite plate operating in the mixture of microorganisms as the electrocatalyst and nutrient as the fuel.…”

Section: Blocking Effectmentioning

confidence: 99%

“…The wearable feature makes the devices more practical for the possible real application. In addition, compared to the BFCs‐based self‐powered electrochemical biosensors published on/before 2015, more self‐powered biosensors consisted of nucleic acid and/or antibody/antigen as the key component of the device rather than the ones containing only enzymes, which resulted in the versatile self‐powered biosensors for the determination of various targets (e. g., ME , glycoproteins , miRNAs , Hg 2+ , AMP , cells , proteins , DNA , ketamine and CEA ). Furthermore, with the rapid growth of the nanomaterials, the nanomaterials (e.g., CNTs , GN , Pt NPs , hPG , AuNPs and NHCSs ) with their distinctive geometries and novel physicochemical properties played an irreplaceable role in the development of the BFCs‐based self‐powered biosensors with superior performance.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

Liu

et al. 2018

Electroanalysis

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The application of biofuel cells (BFCs) for the construction of self‐powered electrochemical biosensors has recently received enormous attention with exciting advancements. The principle of BFCs for electrochemical biosensing is that the BFCs’ power output which is directly extracted by the biological reactions with the help of biocatalysts is closely related to the analyte's concentration. Such unique feature makes BFCs based electrochemical biosensors with two‐electrode system to be operated without the need of any external power source, which provides a more effective way for the miniaturization and convenient construction of electrochemical biosensors than the traditional electrochemical biosensors with three‐electrode system. Following our previous reviews (Electroanalysis 2012, 24, 197–209; Electroanalysis 2015, 27, 1786–1801), the current review is focused on the recent development and advances in the construction of BFCs based self‐powered electrochemical biosensors which are reported in the years between 2015 and 2018, with a particular emphasis on their possible practical applications in the fields of medical diagnosis, environmental monitoring, food analysis and wearable devices. For these reported BFCs‐based self‐powered electrochemical biosensors, the design approaches are still within the scope of effects (i.e., substrate, inhibition, blocking, gene regulation, enzyme, co‐stabilization, competition, and hybrid effects) summarized by our previous reviews. The outlook, challenges and developing tendency of the future research for the construction of BFCs based self‐powered electrochemical biosensor are discussed in the end. We expect that the advanced electrochemical biosensors based on BFCs with the unique self‐powered capability will continue attracting increasing research interest and lead to new opportunities in various attractive applications related to analytical chemistry.

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Section: Blocking Effectmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

Liu

et al. 2018

Electroanalysis

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“…The measured quantities then are converted into signal voltage to a processor. Asghary et al 7 used a dual‐chambered MFC as a power supply to construct an analytical device in monitoring the DNA immobilization and hybridization events. MFCs can be used as a self‐powered as well due to their sensitivity to physicochemical and biological properties in surrounding environments.…”

Section: Introductionmentioning

confidence: 99%

Effect of electrode spacing on the performance of microbial fuel cells with a honeycomb flow straightener

Wang

Jang

2020

Int J Energy Res

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Microbial fuel cells (MFCs) are bioelectrochemical transducers that can be used to produce electrical power under the activity of microbes during the wastewater treatment processes. In the present study, the electrode spacing was considered as a parameter to investigate the influence on the performance of MFCs. The electrode spacing was defined as the distance of the anode electrode plate to the polymer exchange membrane in the MFCs. Three values were set at 0.0, 3.0, and 6.0 cm, respectively. In addition, a flow device, like a honeycomb type flow straightener, was introduced and implemented in the anode chamber for creating a uniform flow. The inner diameter of the honeycomb was 0.7 cm. Results showed that a higher limiting current density with 4108.7 mA/m 2 and a lower resistance with 2.51 Ω can be found in the case of the 0.0 cm electrode spacing. These results also indicated that the shorter electrode spacing with flow straightener devices would improve the performance of MFCs, leading to lower internal resistance and higher power density. In addition, the scanning electron microscopy was employed to analyze the biofilm thickness for MFCs with different electrode spacing. It was also found that the biofilm thickness with 0 cm electrode spacing was larger than the other two cases, leading to a lower internal resistance in the MFCs.

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“…However, some of the above-mentioned methods require expensive agents, complicated operation, and extra powered instruments, making them not suitable for point-of-care and on-site application. Recently, self-powered sensors based on biofuel cells (BFCs), along with the efficiency of electrochemical energy conversion with the biocatalytic property of biocatalyst, are drawing enormous attention. − Due to the capability for detection without external power sources, simplifying the fabrication, minimizing the scale, and reducing the cost, the self-powered biosensors based on BFCs are considered to be especially beneficial for the miniaturization of detection for point-of-care and on-site application in near future. Followed by the first BFCs-based self-powered sensors, BFCs-based self-powered system has been used as sensitive and selective method for the detection of cysteine, cyanide, acetaldehyde, cell, explosives, etc.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Surface Protein-Imprinted Biofuel Cell for Sensitive Self-Powered Glycoprotein Detection

Ouyang

Liu

Han

et al. 2016

ACS Appl. Mater. Interfaces

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Glycoproteins are important biomarkers and therapeutic targets in clinical diagnostics. The conventional analytical methods for glycoprotein are usually faced with some challenges, such as the complex pretreatment of samples, poor availability, and limited stability of antibody, making them not suitable for point-of-care and on-site application. Herein, we demonstrate a novel miniaturized biofuel cells (BFCs)-based self-powered nanosensor for the specific and sensitive determination of glycoproteins in complex samples through the combination of boronate-affinity molecularly imprinted polymer (MIP) and the boronate affinity functionalized biliroxidase-carbon nanotube nanocomposites. The above MIP and the nanocomposites act as both signal probe and biocatalyst at the cathode. The as-obtained self-powered MIP-BFC-based biosensor can detect horseradish peroxidase (a type of glycoprotein) with a wide linear range of 1 ng/mL to 10 μg/mL and a very low detection limit of 1 ng/mL. Especially, it shows high tolerance for different interferences (e.g., sugars and other glycoproteins) and can even measure the α-fetoprotein level in serum samples. Moreover, it exhibits significant advantages over the conventional assays in terms of cost efficiency, stability, and speed, especially inexpensive instrument needed. Our novel approach for construction of the sensor paves a simple and economical way to fabricate portable devices for point-of-care and on-site application.

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A novel self-powered and sensitive label-free DNA biosensor in microbial fuel cell

Cited by 27 publications

References 21 publications

Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

Effect of electrode spacing on the performance of microbial fuel cells with a honeycomb flow straightener

Fabrication of Surface Protein-Imprinted Biofuel Cell for Sensitive Self-Powered Glycoprotein Detection

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