A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities

Shu, Shuangjie; Dai, Antao; Wang, Jiang; Wang, Bin; Yang, Feng; Li, Jia; Cai, Xiaoqing; Yang, Dehua; Ma, Dakota; Wang, Mingwei; Liu, Hong

doi:10.1016/j.bmc.2018.02.036

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…The synthesis of designed analogue is shown in Scheme-I. Chalcone analogues (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) were synthesized from dehydroacetic acid (1) and substituted benzaldehydes (2) via condensation reaction as earlier reported procedure.…”

Section: Resultsmentioning

confidence: 99%

“…Due to this reason and in an attempt to get better biological profile several research groups were interested in preparation of pyrazole analogues of many biologically active natural compounds and investigating their biological potential. Moreover, pyrazole derivatives of curcumin were synthesized and investigated for lipoxygenase inhibitory activity [16], cytotoxic activity [17,18] and antioxidant activity [19]. In addition to this curcumin has been shown to have synergistic effects with artemisinin against Plasmodium berghei [20,21].…”

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confidence: 99%

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Synthesis of New Dihydropyrazoles of Designed Curcumin Analogues

Tripathi

2019

Asian J. Chem.

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Present work demonstrates a facile synthesis of a series of 20 dihydropyrazole derivatives from well designed curcumin analogues by reaction of chalcone derivatives with phenylhydrazine. All the synthesized compounds were characterized by spectroscopic (1H and 13C NMR, IR spectra), spectrometric (Mass spectra) data and elemental analysis. Synthesized dihydropyrazoles have diversity points on attached phenyl ring. Effect of substituent on reactivity was explained on the basis of electronic effect generated due to groups on phenyl ring. Presence of dd (double doublet) in 1H NMR spectrum of dihydropyrazoles was also explained due to presence of optically active carbon of pyrazole ring.

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