A novel serum-stable liver targeted cytotoxic system using valerate-conjugated chitosan nanoparticles surface decorated with glycyrrhizin

El-Marakby, Eman M.; Hathout, Rania M.; Taha, Ismail; Mansour, Samar; Mortada, Nahed D.

doi:10.1016/j.ijpharm.2017.03.081

Cited by 41 publications

(20 citation statements)

References 95 publications

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“…Based on the literature we applied ninhydrin assay for chitosan nanoparticle analysis [ 36 ]. For example, the ninhydrin assay has been successfully used for the study of CS NPs interaction with ligands such as glycyrrhizin and ferulic acid [ 50 ]. The decreased absorbance of Ruhemann’s purple indicated reduced amino group content of chitosan nanoparticles which could be considered as an additional evidence of the successful conjugation of selected ligands to the surface of chitosan nanoparticles [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, the ninhydrin assay has been successfully used for the study of CS NPs interaction with ligands such as glycyrrhizin and ferulic acid [ 50 ]. The decreased absorbance of Ruhemann’s purple indicated reduced amino group content of chitosan nanoparticles which could be considered as an additional evidence of the successful conjugation of selected ligands to the surface of chitosan nanoparticles [ 50 ]. Based on our results, the ninhydrin assay allows not only interaction determination but could give a reliable data about nanoparticle formation (see Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

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Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

et al. 2017

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This work investigated the preparation of chitosan nanoparticles used as carriers for doxorubicin for targeted cancer delivery. Prepared nanocarriers were stabilized and functionalized via zinc ions incorporated into the chitosan nanoparticle backbone. We took the advantage of high expression of sarcosine in the prostate cancer cells. The prostate cancer targeting was mediated by the AntiSar antibodies decorated surface of the nanocage. Formation of the chitosan nanoparticles was determined using a ninhydrin assay and differential pulse voltammetry. Obtained results showed the strong effect of tripolyphosphine on the nanoparticle formation. The zinc ions affected strong chitosan backbone coiling both in inner and outer chitosan nanoparticle structure. Zinc electrochemical signal depended on the level of the complex formation and the potential shift from −960 to −950 mV. Formed complex is suitable for doxorubicin delivery. It was observed the 20% entrapment efficiency of doxorubicin and strong dependence of drug release after 120 min in the blood environment. The functionality of the designed nanotransporter was proven. The purposed determination showed linear dependence in the concentration range of Anti-sarcosine IgG labeled gold nanoparticles from 0 to 1000 µg/mL and the regression equation was found to be y = 3.8x − 66.7 and R2 = 0.99. Performed ELISA confirmed the ability of Anti-sarcosine IgG labeled chitosan nanoparticles with loaded doxorubicin to bind to the sarcosine molecule. Observed hemolytic activity of the nanotransporter was 40%. Inhibition activity of our proposed nanotransporter was evaluated to be 0% on the experimental model of S. cerevisiae. Anti-sarcosine IgG labeled chitosan nanoparticles, with loaded doxorubicin stabilized by Zn ions, are a perspective type of nanocarrier for targeted drug therapy managed by specific interaction with sarcosine and metallothionein for prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

et al. 2017

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“…Here, the results showed a cell viability of 70.6% at a concentration of 300 µg/mL, indicating that the nanoparticles had biocompatibility and non-toxicity. The release of ferulic acid from chitosan nanoparticles loaded with ferulic acid reached 13.34% of the total injected dose after 6 h, showing that the nanoparticles could effectively deliver ferulic acid to the liver [111].…”

Section: Liver-targeted Deliverymentioning

confidence: 94%

“…Typically, liver targeting systems employ reticulated endothelial passive capture microparticles or active targeting based on recognition between liver receptors and ligand-bearing microparticles [111]. Fatty-acid-modified quaternary ammonium chitosan derivative nanoparticles were used as a carrier to deliver insulin into the liver, and the results showed that the nanoparticles had a higher hepatocyte uptake and a better anti-diabetic efficacy [80].…”

Section: Liver-targeted Deliverymentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

654

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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“…They reported a sharp reduction in particle size (up to 62% of original size) prepared from the native chitosan, whereas modified chitosan showed slight increase in the size from 87.39±1.56 nm to 122.33±1.95 nm after 2 h incubation with the serum. After 24 h incubation no significant changes were noticed [211]. Oliveira et al (2017), tested uncoated and poly allylamine hydrochloride (PAH)coated PLGA-NPs in biological environments: BSA solution, mouse and human plasma.…”

Section: Stability Of Npsmentioning

confidence: 99%

Peptide based drug delivery systems to the brain

Islam

Leach

Smith³

et al. 2020

Nano Express

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With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers and society at large. In the last two decades, numerous strategies and technologies have been developed and adapted to achieve drug penetration into the brain, evolving alongside our understanding of the physiological barriers between the brain and surrounding tissues. The blood brain barrier (BBB) has been known as the major barrier for drug delivery to the brain. Both invasive and minimally-invasive approaches have been investigated extensively, with the minimallyinvasive approaches to drug delivery being more suitable. Peptide based brain targeting has been explored extensively in the last two decades. In this review paper, we focused on self-assembled peptides, shuttle peptides and nanoparticles drug delivery systems decorated/conjugated with peptides for brain penetration.Abbreviations

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A novel serum-stable liver targeted cytotoxic system using valerate-conjugated chitosan nanoparticles surface decorated with glycyrrhizin

Cited by 41 publications

References 95 publications

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

Chitosan Derivatives and Their Application in Biomedicine

Peptide based drug delivery systems to the brain

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