A novel single-nucleotide polymorphism of thevisfatin gene and its associations with performance traits in the chicken

Han, Ruili; Lan, Xianyong; Zhang, L. Z.; Ren, Gang; Jing, Y. J.; Li, M. J.; Zhang, B.; Zhao, Mingfei; Guo, Yue-Liang Leon; Kang, Xiangtao; Chen, H.

doi:10.1007/bf03195711

Cited by 24 publications

(11 citation statements)

References 24 publications

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“…In this study, a Gushi-Anka F 2 resource population as previously described by Han et al (2010Han et al ( , 2011 was used to investigate the allele frequency. The population was a cross of Gushi chicken and Anka broilers, representing the slow-growing and the fast-growing broiler, respectively.…”

Section: Resource Populations and Traits For Association Analysismentioning

confidence: 99%

SNP in pre-miR-1666 decreases mature miRNA expression and is associated with chicken performance

Wang

et al. 2015

Genome

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Polymorphisms in miRNA genes could potentially alter various biological processes by influencing the processing and (or) target selection of miRNAs. The rs14120863 (C > G) mutation, which we characterized in a Gushi-Anka F2 resource population, resides in the precursor region of miR-1666. Association analysis with chicken carcass and growth traits showed that the SNP was significantly associated with carcass weight, evisceration weight, breast muscle weight, leg muscle weight, and body weight at 8 weeks of age, as well as some body size indexes including shank girth, chest breadth, breast bone length, and body slanting length, in the Gushi-Anka F2 resource population. Quantitative RT-PCR results showed that miR-1666 expression levels in muscle tissues differed within various genotypes. Experiment in DF1 cells further confirmed that the SNP in miR-1666 could significantly alter mature miRNA production. Subsequently, using dual-luciferase report assay, we verified that miR-1666 could perform its function through targeting of the CBFB gene. In conclusion, the SNP in the precursor of miR-1666 could significantly reduce mature miR-1666 production. It may further affect the function of miR-1666 through the target gene CBFB, hence it is associated with chicken growth traits.

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Section: Resource Populations and Traits For Association Analysismentioning

confidence: 99%

SNP in pre-miR-1666 decreases mature miRNA expression and is associated with chicken performance

Wang

et al. 2015

Genome

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“…A total of 860 chickens from a Gushi-Anka F2 resource population as previously described by Han et al (2010Han et al ( , 2011 were used to investigate the allele frequency. The flock was a cross of Gushi chicken, representing a slow-growing Chinese native chicken breed, and Anka broilers, representing a fast-growing broiler.…”

Section: Study Populationmentioning

confidence: 99%

Association study of polymorphisms inside the miR-1657 seed region with chicken growth and meat traits

Sun

et al. 2012

British Poultry Science

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1. Polymorphisms occurring in the seed region of microRNAs (miRNAs) could influence their target gene and lead to phenotypic variation. The purpose of the research was to explore the genetic effects of the rs14934924 (G > A) mutation resident in the conserved seed region of miR-1657 on growth and meat traits of the Gushi-Anka F2 resource population. 2. The NdeI polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and association analysis were used to analyse the polymorphism. 3. The mutation was associated with body weight at 8 weeks of age, shank girth at 12 weeks of age, breast bone length at 12 weeks of age, pelvis breadth at 4 weeks of age and subcutaneous fat thickness (P < 0·05) and was associated with body weight at 4, 6, 10 and 12 weeks of age (P < 0·01). 4. Our results will be a useful resource for a subsequent study in miRNA function, and provide a basis for molecular techniques in chicken breeding.

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“…Similarly, Fig. 1a showed that the allele A and C were both absent in LLH at rs314901473 and rs316142388, respectively, while individuals with these two alleles were reported to have better growth performance at early growth stage in F2 resource population made up of the reciprocal cross between Gushi chicken and Anka broilers and at late growth stage in Jinghai yellow chickens, respectively (Table 1) [17,22]. Although the frequency of allele A in CB was the highest among all seven chicken populations, the genotype GG was still the primary genotype in all chicken populations at rs314901473.…”

Section: Discussionmentioning

confidence: 89%

“…To characterize the genetic variations and genetic relationships among different populations using DNA markers, a total of 28 identified SNP markers, including 14 growth or carcass traits associated loci and 14 egg laying related genome positions, were selected from the previous reports [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. By using the MassArray technology, an Agena Bioscience MassARRAY System which is capable of efficiently genotyping tens to hundreds of SNPs with high accuracy, we detected the genotype frequency distributions of the 28 SNP markers in seven populations including four lowly selected as well as one moderately selected Sichuan native chicken populations, one commercial broiler line and one commercial layer line [34,35].…”

Section: Introductionmentioning

confidence: 99%

Genotype frequency distributions of 28 SNP markers in two commercial lines and five Chinese native chicken populations

Zhang

Ren

et al. 2020

BMC Genet

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Background: Modern breeding in the poultry industry mainly aims to produce high-performance poultry lines and breeds in two main directions of productivity, meat and eggs. To understand more about the productive potential of lowly selected Chinese native chicken populations, we selected 14 representative SNP markers strongly associated with growth traits or carcass traits and 14 SNP markers strongly associated with egg laying traits through previous reports. By using the MassArray technology, we detected the genotype frequency distributions of these 28 SNP markers in seven populations including four lowly selected as well as one moderately selected Sichuan native chicken populations, one commercial broiler line and one commercial layer line. Results: Based on the genotype frequency distributions of these 28 SNP markers in 5 native chicken populations and 2 commercial lines, the results suggested that these Chinese indigenous chicken populations have a relatively close relationship with the commercial broiler line but a marked distinction from the commercial layer line. Two native chicken breeds, Shimian Caoke Chicken and Daheng Broilers, share similar genetic structure with the broiler line. Conclusions: Our observations may help us to better select and breed superior domestic chickens and provide new clues for further study of breeding programs in local chicken populations.

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A novel single-nucleotide polymorphism of thevisfatin gene and its associations with performance traits in the chicken

Cited by 24 publications

References 24 publications

SNP in pre-miR-1666 decreases mature miRNA expression and is associated with chicken performance

SNP in pre-miR-1666 decreases mature miRNA expression and is associated with chicken performance

Association study of polymorphisms inside the miR-1657 seed region with chicken growth and meat traits

Genotype frequency distributions of 28 SNP markers in two commercial lines and five Chinese native chicken populations

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