“…Activation of HSF1 leads to its nuclear translocation and induction of more than 3000 genes; including the classical molecular chaperone genes such as HSP70, Hdj1, Hdj4, Hdj6, HSP27 and HSP25, as well as the non-classical heat shock genes (Song et al, 2010; Islam et al, 2013). For that reason, drug-induced activation of HSR has been used as an experimental strategy to show that induction of HSR offers strong cell protection in cellular, worm, fly, and mouse or rat models (e.g., Lu et al, 2002; Harrison et al, 2008; Batulan et al, 2006; Neef et al, 2010; Liu et al, 2011; Verma et al, 2014; Ambade et al, 2014; Cha et al, 2014). However, activation of HSF1 may also have undesired effects.…”