A Novel Spider Peptide that Affects the Voltage Gated Potassium Channel Kv1.5

Venoms from the deadliest animals, including spiders, scorpions, bees, and centipedes, are composed of a complex mixture of various peptides developed to catch prey and defend other animals. Venoms are composed of several bioactive molecules such as proteins and peptides that modify physiological conditions in other organisms. These bioactive peptides penetrate tissues and blood vessels to encounter numerous receptors and ion channels, and modulate their activities. Venoms are being employed to treat various medical issues, including cardiovascular diseases. Venom peptides regulate several ion channel behaviors, such as voltage-gated sodium (Nav), calcium (Cav) and potassium (Kv) channels, and are set as a therapeutic approach. In this perspective, we emphasized the isolated lethal venomous peptides' effects on cardiac ionic channels and their mechanisms of action for the cure. We also summarize the highlights and molecular details of their toxin-receptor interactions and prospects to develop peptide therapeutics for respective cardiac electrophysiological diseases.

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Venomous Peptides as Cardiac Ion Channel’s Modulators

Junapudi¹,

Yerramsetty

Chopra

et al. 2022

VAT

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A Novel Spider Peptide that Affects the Voltage Gated Potassium Channel Kv1.5

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Venomous Peptides as Cardiac Ion Channel’s Modulators

Venomous Peptides as Cardiac Ion Channel’s Modulators

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