A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC–TOFMS with multivariate statistical analysis

A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect

“…Li et al stated that the two components, leonuride or its isomer and 5-GGMF, were used as potential chemical markers for the discrimination of raw and processed RG [10]. In this study, we observed the obviously increased 5-HMF and 5-GMF, and the decreased glycoside in the processed RG.…”

“…Metabolomics has also been used to differentiate herbal medicine of different origins and to identify characteristic components. Li et al developed a novel strategy with metabolomics to identify potential marker components in order to differentiate raw and processed RG [10]. Because both the TCM samples and the biological samples are amenable to metabolomics, linking the chemical fingerprints of TCM to the biological effect observed after TCM administration is a reasonable approach to devise a new TCM quality control method.…”

Identification of chemical constituents in SiWu decoction by UHPLC-DAD-TOF/MS

“…The two ions were deduced to be [M+HCOO] − and [M-H] − , respectively, and the empirical molecular formula was presumed to be C 27 H 42 O 20 , which matches that of rehmannioside D [7,18]. Compound 5 was next to compound 4, it exhibited ions at m/z 523.1633 and 569.1688, which were deduced to be [M-H] − and [M+HCOO] − , respectively.…”

“…Previous chemical studies of SWD were all based on the qualitation and quantitation of some major compounds, effective fractions, or the chemical composition of the four individual drugs [3][4][5][6][7][8][9]. To our knowledge, the comprehensive chemical analysis of the formula is still lacking.…”

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

“…An ideal chemical marker should be not only characteristic but also therapeutic constituent. Li et al reported on a method to rapidly determine potential chemical markers for the discrimination and quality control of raw and processed Radix Rehmanniae using UHPLC-TOF-MS coupled with multivariate statistical analysis [148]. Raw and processed herbs have different effects according to TCM theory.…”