A Novel Substituted Guanidine with High Activity in vitro against Rhinoviruses

Abstract

In brief, the sole basis of Galimov's claim, in connection with his postulated mechanism, that "there are no limitations involving the total concentration of carbon in the medium" is his complete disregard of such limitations, which are inescapable. F. C. FRANK

Replication of rhinoviruses

“…Compounds with activity of fractions of a microgram have also been reported (10,108). Compounds with activity of fractions of a microgram have also been reported (10,108).…”

Picornavirus inhibitors

“…It is active against some members of the Picornaviridae and Togaviridae families (Friedman, 1970) and is, in many ways, a model inhibitor of poliovirus, despite the fact that it is one of the least potent agents against viral RNA synthesis (0.2-3 mM) (Tershak, 1974(Tershak, , 1982. Several guanidine derivatives have nevertheless been synthesized with more potent antiviral activity (Bucknall et al, 1973). Soon after the discovery of guanidine as an antiviral agent (Rightsel et al, 1961), poliovirus mutants resistant to or dependent on guanidine were described (Loddo et al, 1963;Nakano et al, 1963).…”

Antiviral agents

“…Coronavirus, influenza, parainfluenza, equine rhinovirus and pseudorabies were not inhibited. While guanidine tested in vitro gives rise to drug-resistant strains very rapidly, this could not be demonstrated with ICI 65709, neither could its action be reversed by compounds such as ethanolamine or methionine which reverse the action of guanidine [350]. Development of the above compounds led to the ureidoguanidines (LXXIII) which, lacking the thiourea group, were less likely to show thyroid toxicity.…”