A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

Wakabayashi, Rie; Ishiyama, Ryutaro; Kamiya, Noriho; Goto, Masahiro

doi:10.1039/c4md00179f

Cited by 5 publications

(9 citation statements)

References 29 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We observed spherical morphologies of Cur-S/W nanodispersions prepared with the two different types of pluronics. This finding is in contrast to that observed in our previous study, where the encapsulated CPT exhibited cubic lamellar morphologies, probably stemming from recrystallization of CPT during the formulation process because of the poor solubility of CPT in cyclohexane (Wakabayashi et al, 2014). However, here the curcumin is moderately soluble in cyclohexane, suggesting that the formation of the curcumin crystals at the early stage of preparation does not occur.…”

Section: Characteristics Of Cur-s/w Nanodispersionscontrasting

confidence: 99%

“…The Cur-S/W nanodispersions with Rho-DOPE were prepared as previously described (Wakabayashi et al, 2014), except that 10 µL of 1 mg/mL Rho-DOPE in methanol was added to the pluronic aqueous solution. Cell internalization of Cur-S/W nanodispersion in HeLa cell was evaluated by confocal laser scanning microscopy (CLSM).…”

Section: Cellular Internalization Studiesmentioning

confidence: 99%

“…However, the EE slightly decreased when the loading concentration of curcumin was increased. The emulsification and freeze drying process can promote high entrapment of the drugs in the presence of the surfactant molecules (Tahara et al, 2012;Wakabayashi et al, 2014). The zeta potential of Cur-S/W nanodispersions for cur-F68_#2 and cur-F127_#2 were −0.75 and 0.71, respectively.…”

Section: Characteristics Of Cur-s/w Nanodispersionsmentioning

confidence: 99%

“…A number of nanocarrier systems loaded with curcumin have been reported to date, such as liposomes (Li et al, 2005), polymer micelles (Gong et al, 2013;Yang et al, 2015), chitosan nanoparticles (Razi et al, 2018a(Razi et al, , 2018b and nanoemulsions (Sari et al, 2015). In the present study, we aimed to improve the solubility and bioavailability of curcumin by developing a new aqueous formulation using the solid-in-water (S/W) nanodispersion technique (Wakabayashi et al, 2014). This novel technique comprises simple preparation protocols: emulsification and freeze-drying for encapsulating hydrophobic biomolecules with a hydrophilic surfactant, followed by redispersion of the resultant solid complexes in an aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

“…This novel technique comprises simple preparation protocols: emulsification and freeze-drying for encapsulating hydrophobic biomolecules with a hydrophilic surfactant, followed by redispersion of the resultant solid complexes in an aqueous solution. Our previous studies have demonstrated that this technique enables the encapsulation of the poorly soluble anticancer drug camptothecin (CPT) with high efficiency and stability (Wakabayashi et al, 2014). Here, we applied this formulation strategy to study the nanodispersion of curcumin in the aqueous phase and characterize the S/W nanodispersion in detail.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique

Hardiningtyas

Wakabayashi

Ishiyama

et al. 2019

J. Chem. Eng. Japan / JCEJ

Self Cite

View full text Add to dashboard Cite

Curcumin (Cur), a hydrophobic polyphenol compound, holds promising potential as an anticancer agent. However, the poor solubility in water and the low bioavailability of curcumin have limited its therapeutic applications. In this regard, we reported the formulation of curcumin using a solid-in-water (S/W) nanodispersion technique to enhance the water solubility and therapeutic activity of curcumin. This new aqueous formulation comprises simple preparation protocols: emulsi cation and freeze-drying for encapsulating hydrophobic biomolecules with a hydrophilic surfactant, followed by redispersion of the resultant solid complexes in an aqueous solution. Pluronics F68 and F127 were used here for the encapsulation of curcumin. Enhanced aqueous solubility of curcumin was achieved by encapsulating curcumin with a hydrophilic surfactant using the S/W nanodispersion technique. The resultant nanosized formulation had a narrow size distribution and high entrapment e ciency of curcumin. The highest loading capacity of curcumin in S/W nanodispersion was obtained with a weight ratio of curcumin to pluronic of 1 : 10 for both surfactants. The release pro le of the complexes was found to depend on the type of surfactant, suggesting that the selection of a proper surfactant is crucial for controlling curcumin delivery. The anticancer activity of the S/W formulation of curcumin was correlated with the drug release pro les and cellular uptake, which in turn was in uenced by the hydrophobicity and chemical structure of the surfactant.

show abstract

Section: Characteristics Of Cur-s/w Nanodispersionscontrasting

confidence: 99%

Section: Cellular Internalization Studiesmentioning

confidence: 99%

Section: Characteristics Of Cur-s/w Nanodispersionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique

Hardiningtyas

Wakabayashi

Ishiyama

et al. 2019

J. Chem. Eng. Japan / JCEJ

Self Cite

View full text Add to dashboard Cite

show abstract

Choline oleate based micellar system as a new approach for Luteolin formulation: Antioxidant, antimicrobial, and food preservation properties evaluation

Shimul

Moshikur

Minamihata

et al. 2022

Journal of Molecular Liquids

View full text Add to dashboard Cite

Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging

Zhang

Chau

et al. 2021

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anti-cancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lanthanide(III) ratio control. This cancer-selective lanthanide-based self-assembled nanocomposite (LnNPs) has been synthesized by conjugating lanthanide-cyclen complexes (cycLn) with a well-known drug -camptothecin (CPT) -through a redox-sensitive disulfide bond (-ss-). By accurately controlling the ratio of Gd(III)-and Yb(III)-complexes, we prepared hybrid nanoparticles (Gd/YbNPs) with both NIR and MR imaging properties. The enhanced stability at ultralow critical aggregation concentrations (CAC), simultaneous optical and MR imaging, improved delivery/chemotherapeutic efficiency, and cancer cell selectivity of such nanomicellar theranostic prodrugs in vitro and in vivo has thus been achieved and validated. The work provides a blueprint combining stimuli-activated NIR luminescence and real-time MR imaging into a safe and biocompatible nanoplatform for selective cancer treatment.

show abstract

A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

Abstract: In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, camptothecin (CPT).

Cited by 5 publications

References 29 publications

Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique

Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique

Choline oleate based micellar system as a new approach for Luteolin formulation: Antioxidant, antimicrobial, and food preservation properties evaluation

Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging

Contact Info

Product

Resources

About