A novel synthesis of some new benzoyl‐substituted heterocycles from 2‐benzoyl‐3‐phenylpent‐2‐ene‐1,5‐dinitrile

Abstract

2‐Benzoyl‐3‐phenylpent‐2‐ene‐1,5‐dinitrile 1 undergoes bromination with N‐bromosuccinimide (NBS) to afford the bromo derivative 2a. This bromo derivative undergoes reactions with sodium hydrogen sulfide, ethyl thioglycollate, hydroxylamine hydrochloride, hydrazines, cyanoacetamide, cyanacetohydrazide and urea derivatives to afford the thiophene 4, 4H‐thiopyran 6, 4H‐1,2‐oxazine 8, 4H‐pyridazines 10a,b, the pyridine 15, pyrrolo[1,2‐b]pyridazine 17 and the N‐substituted‐pyrrole derivatives 19a‐c respectively.

Multi‐Component Approach for Synthesis of Quinolinyl‐1,4‐dihydropyridines, Evaluation of Cytotoxicity against MCF7 and Molecular Docking Studies

“…Mehdi Ghandi et al [7] in 2015 reported a series of quinolinyl-1,4-dihydropyridines, where the À NH 2 proton peak was shown to appear around 6.36-6.43 ppm as a broad singlet. In another report, [27] for 4-aryl-1,4-dihydropyridine À NH 2 proton peak appeared at 7.85 ppm as a broad singlet. In 2014 Chetan B. Snagani et al reported a series of quinolinyl-1,4-dihydropyridines in which À NH 2 proton peak was shown to appear around 7.08 ppm as a singlet.…”

Vorschau 8/2016

“…In the past decade, we have been involved in a program aiming at the synthesis of new heterocyclic compounds that may possess biologically active properties to be used as potential biodegradable agrochemicals [2–5]. In continuation of our earlier interest in 3(5)‐aminopyrazole, we report here an efficient synthesis of the hitherto unreported ethyl 5‐amino‐3‐phenyl‐1 H ‐pyrazole‐4‐carboxylate 3 and its exploitation for the synthesis of some new fused pyrazole derivatives.…”

Phenacyl Bromides Revisited: Facile Synthesis of Some New Pyrazoles, Pyridazines, and Their Fused Derivatives

“…In the past few years, we have been involved in a program aimed at the synthesis of some new heterocyclic systems of biological interest to be tested as biodegradable agrochemicals . In the context of this program, we have previously reported several syntheses starting from 2‐bromo‐1‐phenylethanone (ω‐bromoacetophenone) 2a (obtained from acetophenone 1 by bromination; Fig.…”