A novel target and biomarker benzothiazolyl–naphthalimide probes for precise and selective detection of serum albumin and anticancer activity

Abstract

N-Benzothiazolyl-1,8-naphthalimide based fluorescent probes were designed and synthesized for selective detection of human serum albumin (HSA) and bovine serum albumin (BSA) among various bioanalytes and further studied for their in vitro anti-proliferative activity against 60 human cancer cell lines.

A microenvironment-sensitive red emissive probe with a large Stokes shift for specific recognition and quantification of serum albumin in complex biofluids and live cells

“…7 For instance, an increased plasma albumin concentration (455 g L À1 ) can cause hyperalbuminemia, which is associated with dehydration. 9 However, hypoalbuminemia, a condition caused by a low quantity of albumin (o35 g L À1 ) in blood plasma, is an indication of chronic hepatitis, liver cirrhosis, heart failure, and stroke. 10,11 On the other hand, excessive amounts of albumin (30-300 mg L À1 ) in the urine can result in microalbuminuria, a condition that has been linked to endothelial dysfunction, post-streptococcal glomerulonephritis, diabetes mellitus and hypertension expressing a primary sign for cardiovascular disease and renal illness.…”